Abstract
Though both clinicians and scientists have long recognized the influence of extracellular calcium on the function of muscle and nervous tissue, recent insights reveal that the mechanisms allowing changes in extracellular calcium to alter cellular excitability have been incompletely understood. For many years the effects of calcium on neuronal signaling were explained only in terms of calcium entry through voltage-gated calcium channels and biophysical charge screening. More recently however, it has been recognized that the calcium-sensing receptor is prevalent in the nervous system and regulates synaptic transmission and neuronal activity via multiple signaling pathways. Here we review the multiplicity of mechanisms by which changes in extracellular calcium alter neuronal signaling and propose that multiple mechanisms are required to describe the full range of experimental observations.
| Original language | English (US) |
|---|---|
| Article number | 116 |
| Journal | Frontiers in Physiology |
| Volume | 7 |
| Issue number | MAR |
| DOIs | |
| State | Published - Mar 30 2016 |
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Keywords
- Action potentials
- Calcium
- Calcium sensing receptor
- Excitability
- Ion channels
- Nervous system
- Synaptic transmission
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Calcium-sensing receptor : A key target for extracellular calcium signaling in neurons. / Jones, Brian L.; Smith, Stephen.
In: Frontiers in Physiology, Vol. 7, No. MAR, 116, 30.03.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium-sensing receptor
T2 - A key target for extracellular calcium signaling in neurons
AU - Jones, Brian L.
AU - Smith, Stephen
PY - 2016/3/30
Y1 - 2016/3/30
N2 - Though both clinicians and scientists have long recognized the influence of extracellular calcium on the function of muscle and nervous tissue, recent insights reveal that the mechanisms allowing changes in extracellular calcium to alter cellular excitability have been incompletely understood. For many years the effects of calcium on neuronal signaling were explained only in terms of calcium entry through voltage-gated calcium channels and biophysical charge screening. More recently however, it has been recognized that the calcium-sensing receptor is prevalent in the nervous system and regulates synaptic transmission and neuronal activity via multiple signaling pathways. Here we review the multiplicity of mechanisms by which changes in extracellular calcium alter neuronal signaling and propose that multiple mechanisms are required to describe the full range of experimental observations.
AB - Though both clinicians and scientists have long recognized the influence of extracellular calcium on the function of muscle and nervous tissue, recent insights reveal that the mechanisms allowing changes in extracellular calcium to alter cellular excitability have been incompletely understood. For many years the effects of calcium on neuronal signaling were explained only in terms of calcium entry through voltage-gated calcium channels and biophysical charge screening. More recently however, it has been recognized that the calcium-sensing receptor is prevalent in the nervous system and regulates synaptic transmission and neuronal activity via multiple signaling pathways. Here we review the multiplicity of mechanisms by which changes in extracellular calcium alter neuronal signaling and propose that multiple mechanisms are required to describe the full range of experimental observations.
KW - Action potentials
KW - Calcium
KW - Calcium sensing receptor
KW - Excitability
KW - Ion channels
KW - Nervous system
KW - Synaptic transmission
UR - http://www.scopus.com/inward/record.url?scp=84964596017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964596017&partnerID=8YFLogxK
U2 - 10.3389/fphys.2016.00116
DO - 10.3389/fphys.2016.00116
M3 - Article
AN - SCOPUS:84964596017
VL - 7
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
IS - MAR
M1 - 116
ER -