Calcium regulating hormones in essential hypertension. Importance of gender

E. W. Young, D. A. McCarron, Cynthia Morris

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Abstract

Alterations of calcium metabolism have been described in human essential hypertension and experimental hypertension. We investigated the interrelationship of parathyroid hormone (PTH) and 1,25(OH)2-vitamin D (1,25(OH)2D) in patients with untreated essential hypertension as compared to normotensive controls. The hypertensive subjects (n = 75; 43 men, 32 women) had a mean blood pressure of 138 ± 8/95 ± 5 mm Hg as compared with 120 ± 11/80 ± 8 in the normotensive group (n = 40; 22 men, 18 women). Serum PTH was measured with an intact molecule immunochemiluminometric assay and 1,25(OH)2D was measured with radioimmunoassay and 1,25(OH)2d was measured with radioimmunoassay after HPLC separation. Hypertensive men had PTH levels that were 36% higher than normotensive men (5.3 ± 2.9 v 3.9 ± 0.8 pmol/L, P = .005). When blood pressure was analyzed as a continuous variable, there was a direct correlation between it and serum PTH in men (r = .31, P = .004). In women, by contrast, there was no difference in serum PTH between hypertensive and normotensive subjects and no relationship between blood pressure and the serum PTH concentration. Blood pressure was inversely correlated with serum phosphorus levels in both sexes (r = -0.20, P = .04). In men, the elevated serum PTH levels and depressed serum phosphorus levels would be higher in the hypertensive subjects. However, that was not observed, as serum 1,25(OH)2D was slightly lower in hypertensive (38.3 ± 15.2 pg/mL) than normotensive men (42.7 ± 11.3, P = .21). In women, 1,25(OH)2D levels were similar in hypertension (38.8 ± 15.1) and normotension (42.1 ± 15.1, P = .36), although serum phosphorus tended to be lower in the hypertensive subjects. Thus, we have identified overtly elevated PTH levels in hypertensive men and 1,25(OH)2D concentrations that are inappropriately low for the prevailing serum PTH and phosphorus concentrations, a biochemical pattern of calcium metabolism not observed in women with elevated arterial pressures.

Original languageEnglish (US)
JournalAmerican Journal of Hypertension
Volume3
Issue number8 II SUPPL.
StatePublished - 1990

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Parathyroid Hormone
Hormones
Calcium
Serum
Phosphorus
Blood Pressure
Radioimmunoassay
Essential Hypertension
Hypertension
Ergocalciferols
Arterial Pressure
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Calcium regulating hormones in essential hypertension. Importance of gender. / Young, E. W.; McCarron, D. A.; Morris, Cynthia.

In: American Journal of Hypertension, Vol. 3, No. 8 II SUPPL., 1990.

Research output: Contribution to journalArticle

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abstract = "Alterations of calcium metabolism have been described in human essential hypertension and experimental hypertension. We investigated the interrelationship of parathyroid hormone (PTH) and 1,25(OH)2-vitamin D (1,25(OH)2D) in patients with untreated essential hypertension as compared to normotensive controls. The hypertensive subjects (n = 75; 43 men, 32 women) had a mean blood pressure of 138 ± 8/95 ± 5 mm Hg as compared with 120 ± 11/80 ± 8 in the normotensive group (n = 40; 22 men, 18 women). Serum PTH was measured with an intact molecule immunochemiluminometric assay and 1,25(OH)2D was measured with radioimmunoassay and 1,25(OH)2d was measured with radioimmunoassay after HPLC separation. Hypertensive men had PTH levels that were 36{\%} higher than normotensive men (5.3 ± 2.9 v 3.9 ± 0.8 pmol/L, P = .005). When blood pressure was analyzed as a continuous variable, there was a direct correlation between it and serum PTH in men (r = .31, P = .004). In women, by contrast, there was no difference in serum PTH between hypertensive and normotensive subjects and no relationship between blood pressure and the serum PTH concentration. Blood pressure was inversely correlated with serum phosphorus levels in both sexes (r = -0.20, P = .04). In men, the elevated serum PTH levels and depressed serum phosphorus levels would be higher in the hypertensive subjects. However, that was not observed, as serum 1,25(OH)2D was slightly lower in hypertensive (38.3 ± 15.2 pg/mL) than normotensive men (42.7 ± 11.3, P = .21). In women, 1,25(OH)2D levels were similar in hypertension (38.8 ± 15.1) and normotension (42.1 ± 15.1, P = .36), although serum phosphorus tended to be lower in the hypertensive subjects. Thus, we have identified overtly elevated PTH levels in hypertensive men and 1,25(OH)2D concentrations that are inappropriately low for the prevailing serum PTH and phosphorus concentrations, a biochemical pattern of calcium metabolism not observed in women with elevated arterial pressures.",
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