Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury

Minghua Li, Koichi Inoue, Hong Fang Si, Zhi Gang Xiong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Brain ischemia is a leading cause of death and long-term disabilities worldwide. Unfortunately, current treatment is limited to thrombolysis, which has limited success and a potential side effect of intracerebral hemorrhage. Searching for new cell injury mechanisms and therapeutic interventions has become a major challenge in the field. It has been recognized for many years that intracellular Ca2+ overload in neurons is essential for neuronal injury associated with brain ischemia. However, the exact pathway(s) underlying the toxic Ca2+ loading remained elusive. This review discusses the role of two Ca2+-permeable cation channels, TRPM7 and acid-sensing channels, in glutamate-independent Ca2+ toxicity associated with brain ischemia.

Original languageEnglish (US)
Pages (from-to)734-740
Number of pages7
JournalActa Pharmacologica Sinica
Volume32
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Glutamate Receptors
Calcium Channels
Brain Ischemia
Brain Injuries
Poisons
Cerebral Hemorrhage
Wounds and Injuries
Cations
Glutamic Acid
Cause of Death
Neurons
Acids
Therapeutics

Keywords

  • acid-sensing ion channel
  • brain ischemia
  • neurons
  • TRPM7

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury. / Li, Minghua; Inoue, Koichi; Si, Hong Fang; Xiong, Zhi Gang.

In: Acta Pharmacologica Sinica, Vol. 32, No. 6, 06.2011, p. 734-740.

Research output: Contribution to journalArticle

Li, Minghua ; Inoue, Koichi ; Si, Hong Fang ; Xiong, Zhi Gang. / Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury. In: Acta Pharmacologica Sinica. 2011 ; Vol. 32, No. 6. pp. 734-740.
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