Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture

Craig E. Jahr, Charles F. Stevens

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

We have developed a quantitative description for calcium permeability of the N-methyl-D-aspartate receptor channel to permit predictions of the reversal potential and calcium influx at different voltages for different extracellular calcium concentrations. Increasing the external calcium concentration markedly shifted the reversal potential to positive values and simultaneously decreased the single-channel conductance at potentials negative to the reversal potential. Very simple quantitative descriptions of calcium permeation and channel block by calcium ions accurately characterize our data and permit the prediction of reversal potentials and magnitudes of calcium influx for a wide range of conditions.

Original languageEnglish (US)
Pages (from-to)11573-11577
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number24
DOIs
StatePublished - Dec 15 1993

Keywords

  • Glutamate receptors
  • Ion permeation
  • Single channel
  • Synapse

ASJC Scopus subject areas

  • General

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