Calcium oxalate retinopathy associated with generalized oxalosis: x ray diffraction and electron microscopic studies of crystal deposits

J. D. Bullock, D. M. Albert, C. W. Skinner, W. H. Miller, J. H. Galla

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Abstract

Crystallographic, light and electron microscopic findings are reported in a previously undescribed entity: calcium oxalate retinopathy associated with generalized oxalosis. The affected patient was a 66 yr old male with a previous history of mild hypertensive renal disease who had undergone prolonged abdominal surgery under methoxyflurane (MOF; Penthrane) anesthesia. He subsequently developed acute irreversible renal failure caused by renal oxalosis as shown by renal biopsy. He was maintained on renal dialysis and, shortly before his death 3 yr later, he was noted to have changes in the fundus oculi suggestive of the flecked retina syndrome. Widespread oxalosis was found at autopsy. Light and electron microscopy revealed particularly heavy depositions within the retinal pigment epithelium. Positive identification of the deposits as the monohydrate form of calcium oxalate was obtained by X ray diffraction investigations.

Original languageEnglish (US)
Pages (from-to)256-265
Number of pages10
JournalInvestigative ophthalmology
Volume13
Issue number4
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • Medicine(all)

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