Calcium oxalate retinopathy associated with generalized oxalosis

x ray diffraction and electron microscopic studies of crystal deposits

J. D. Bullock, Daniel Albert, C. W. Skinner, W. H. Miller, J. H. Galla

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Crystallographic, light and electron microscopic findings are reported in a previously undescribed entity: calcium oxalate retinopathy associated with generalized oxalosis. The affected patient was a 66 yr old male with a previous history of mild hypertensive renal disease who had undergone prolonged abdominal surgery under methoxyflurane (MOF; Penthrane) anesthesia. He subsequently developed acute irreversible renal failure caused by renal oxalosis as shown by renal biopsy. He was maintained on renal dialysis and, shortly before his death 3 yr later, he was noted to have changes in the fundus oculi suggestive of the flecked retina syndrome. Widespread oxalosis was found at autopsy. Light and electron microscopy revealed particularly heavy depositions within the retinal pigment epithelium. Positive identification of the deposits as the monohydrate form of calcium oxalate was obtained by X ray diffraction investigations.

Original languageEnglish (US)
Pages (from-to)256-265
Number of pages10
JournalInvestigative ophthalmology
Volume13
Issue number4
StatePublished - Dec 1 1974
Externally publishedYes

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Hyperoxaluria
Calcium Oxalate
Methoxyflurane
X-Rays
Electrons
Kidney
Fundus Oculi
Light
Retinal Pigment Epithelium
Acute Kidney Injury
X-Ray Diffraction
Renal Dialysis
Retina
Autopsy
Electron Microscopy
Anesthesia
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Calcium oxalate retinopathy associated with generalized oxalosis : x ray diffraction and electron microscopic studies of crystal deposits. / Bullock, J. D.; Albert, Daniel; Skinner, C. W.; Miller, W. H.; Galla, J. H.

In: Investigative ophthalmology, Vol. 13, No. 4, 01.12.1974, p. 256-265.

Research output: Contribution to journalArticle

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