Abstract
Purpose of Review: Previous epidemiological studies reported equivocal associations between calcium intake and cancer risk by organ site. Here, we summarized the latest evidence on associations between calcium intake and risk of major cancers (lung, breast, prostate, and colorectal cancers) from epidemiological studies and the potential molecular mechanisms supporting such associations. Recent Findings: In observational studies, calcium intake from food and/or supplements was inversely associated with risk of colorectal and breast cancers and suggestively inversely associated with lung cancer risk, whereas it was positively associated with prostate cancer risk. In trials of calcium-containing supplements, a protective effect was suggested for prostate cancer and no consistent effects for colorectal, breast, and lung cancers. Potential molecular mechanisms by cancer site are discussed. Summary: More studies are needed to evaluate associations between cancer and sources of calcium intake, and to further elucidate potential molecular mechanisms and how these may differ by cancer site.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 72-79 |
| Number of pages | 8 |
| Journal | Current Nutrition Reports |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2017 |
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Keywords
- Breast cancer
- Calcium intake
- Colorectal cancer
- Lung cancer
- Prostate cancer
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
Cite this
Calcium Intake and Cancer Risk : Current Evidence and Future Research Directions. / Booth, Georgeann C.; Zhang, Zhenzhen; Shannon, Jackilen (Jackie); Bobe, Gerd; Takata, Yumie.
In: Current Nutrition Reports, Vol. 6, No. 2, 01.06.2017, p. 72-79.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Calcium Intake and Cancer Risk
T2 - Current Evidence and Future Research Directions
AU - Booth, Georgeann C.
AU - Zhang, Zhenzhen
AU - Shannon, Jackilen (Jackie)
AU - Bobe, Gerd
AU - Takata, Yumie
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Purpose of Review: Previous epidemiological studies reported equivocal associations between calcium intake and cancer risk by organ site. Here, we summarized the latest evidence on associations between calcium intake and risk of major cancers (lung, breast, prostate, and colorectal cancers) from epidemiological studies and the potential molecular mechanisms supporting such associations. Recent Findings: In observational studies, calcium intake from food and/or supplements was inversely associated with risk of colorectal and breast cancers and suggestively inversely associated with lung cancer risk, whereas it was positively associated with prostate cancer risk. In trials of calcium-containing supplements, a protective effect was suggested for prostate cancer and no consistent effects for colorectal, breast, and lung cancers. Potential molecular mechanisms by cancer site are discussed. Summary: More studies are needed to evaluate associations between cancer and sources of calcium intake, and to further elucidate potential molecular mechanisms and how these may differ by cancer site.
AB - Purpose of Review: Previous epidemiological studies reported equivocal associations between calcium intake and cancer risk by organ site. Here, we summarized the latest evidence on associations between calcium intake and risk of major cancers (lung, breast, prostate, and colorectal cancers) from epidemiological studies and the potential molecular mechanisms supporting such associations. Recent Findings: In observational studies, calcium intake from food and/or supplements was inversely associated with risk of colorectal and breast cancers and suggestively inversely associated with lung cancer risk, whereas it was positively associated with prostate cancer risk. In trials of calcium-containing supplements, a protective effect was suggested for prostate cancer and no consistent effects for colorectal, breast, and lung cancers. Potential molecular mechanisms by cancer site are discussed. Summary: More studies are needed to evaluate associations between cancer and sources of calcium intake, and to further elucidate potential molecular mechanisms and how these may differ by cancer site.
KW - Breast cancer
KW - Calcium intake
KW - Colorectal cancer
KW - Lung cancer
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85057640861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057640861&partnerID=8YFLogxK
U2 - 10.1007/s13668-017-0193-y
DO - 10.1007/s13668-017-0193-y
M3 - Review article
AN - SCOPUS:85057640861
VL - 6
SP - 72
EP - 79
JO - Current Nutrition Reports
JF - Current Nutrition Reports
SN - 2161-3311
IS - 2
ER -