Calcium-dependent polymerization of lactoferrin

Robert (Rob) Bennett, Grover C. Bagby, Julianne Davis

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    Lactoferrin is known to have a molecular weight of approximately 77,000. In this study, we show that it undergoes polymerization in calcium-containing fluids and that the predominant species is a tetramer. Preliminary evidence is presented to indicate that the tetramer is also found in human serum, tears and breast milk. When the lactoferrin monomer and the tetramer were tested for biological activity in a system that is known to be highly sensitive to an inhibitory effect of lactoferrin - the production of granulocyte monocyte colony-stimulating activity - it was found that only the monomeric form of lactoferrin was inhibitory.

    Original languageEnglish (US)
    Pages (from-to)88-95
    Number of pages8
    JournalBiochemical and Biophysical Research Communications
    Volume101
    Issue number1
    DOIs
    StatePublished - Jul 16 1981

    Fingerprint

    Lactoferrin
    Polymerization
    Calcium
    Human Milk
    Bioactivity
    Tears
    Granulocytes
    Monocytes
    Monomers
    Molecular Weight
    Molecular weight
    Fluids
    Serum

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Calcium-dependent polymerization of lactoferrin. / Bennett, Robert (Rob); Bagby, Grover C.; Davis, Julianne.

    In: Biochemical and Biophysical Research Communications, Vol. 101, No. 1, 16.07.1981, p. 88-95.

    Research output: Contribution to journalArticle

    Bennett, Robert (Rob) ; Bagby, Grover C. ; Davis, Julianne. / Calcium-dependent polymerization of lactoferrin. In: Biochemical and Biophysical Research Communications. 1981 ; Vol. 101, No. 1. pp. 88-95.
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