Calcium dependence of spontaneous neurotransmitter release

Courtney L. Williams, Stephen Smith

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Spontaneous release of neurotransmitters is regulated by extracellular [Ca2+] and intracellular [Ca2+]. Curiously, some of the mechanisms of Ca2+ signaling at central synapses are different at excitatory and inhibitory synapses. While the stochastic activity of voltage-activated Ca2+ channels triggers a majority of spontaneous release at inhibitory synapses, this is not the case at excitatory nerve terminals. Ca2+ release from intracellular stores regulates spontaneous release at excitatory and inhibitory terminals, as do agonists of the Ca2+-sensing receptor. Molecular machinery triggering spontaneous vesicle fusion may differ from that underlying evoked release and may be one of the sources of heterogeneity in release mechanisms.

Original languageEnglish (US)
JournalJournal of Neuroscience Research
DOIs
StateAccepted/In press - 2017

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Keywords

  • Calcium
  • Minis
  • Spontaneous release
  • VGCC (voltage-gated calcium channels)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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