@article{067adabe7b1b40019f3ffc22566b1e83,
title = "Calcium dependence of spontaneous neurotransmitter release",
abstract = "Spontaneous release of neurotransmitters is regulated by extracellular [Ca2+] and intracellular [Ca2+]. Curiously, some of the mechanisms of Ca2+ signaling at central synapses are different at excitatory and inhibitory synapses. While the stochastic activity of voltage-activated Ca2+ channels triggers a majority of spontaneous release at inhibitory synapses, this is not the case at excitatory nerve terminals. Ca2+ release from intracellular stores regulates spontaneous release at excitatory and inhibitory terminals, as do agonists of the Ca2+-sensing receptor. Molecular machinery triggering spontaneous vesicle fusion may differ from that underlying evoked release and may be one of the sources of heterogeneity in release mechanisms.",
keywords = "VGCC (voltage-gated calcium channels), calcium, minis, spontaneous release",
author = "Williams, {Courtney L.} and Smith, {Stephen M.}",
note = "Funding Information: This work was supported by grants awarded by NIGMS (R01 GM097433) and the U.S. Department of Veterans Affairs (BX002547) to S.M.S. In addition, C.L.W. was supported by NHLBI (T32HL083808) and NINDS (1F31NS083309). We thank Caitlin Harrington-Smith for assistance with figures. Both authors had full access to all the data in the study and take responsibility for the integrity of the data and the analysis. Study concept and design: SMS and CLW; acquistion of the data and analysis: CLW and SMS; drafting and revision of the manuscript: CLW and SMS. Funding Information: This work was supported by grants awarded by NIGMS (R01 GM097433) and U.S. Department of Veterans Affairs (BX002547) to S.M.S. In addition, C.L.W. was supported by NHLBI (T32HL083808) and NINDS (1F31NS083309). Funding Information: This work was supported by grants awarded by NIGMS (R01 GM097433) and the U.S. Department of Veterans Affairs (BX002547) to S.M.S. In addition, C.L.W. was supported by NHLBI (T32HL083808) and NINDS (1F31NS083309). We thank Caitlin Harrington-Smith for assistance with figures. Publisher Copyright: Published 2017. This article is a U.S. Government work and is in the public domain in the USA.",
year = "2018",
month = mar,
doi = "10.1002/jnr.24116",
language = "English (US)",
volume = "96",
pages = "335--347",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "3",
}