Calcium dependence of neurotransmitter release

Gary Matthews; Henriquevon Gersdorff

doi:10.1006/smns.1996.0040

Calcium dependence of neurotransmitter release

Gary Matthews, Henriquevon Gersdorff

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca²⁺] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca²⁺] in this microdomain, together with the fast Kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.

Original language	English (US)
Pages (from-to)	329-334
Number of pages	6
Journal	Seminars in the Neurosciences
Volume	8
Issue number	5
DOIs	https://doi.org/10.1006/smns.1996.0040
State	Published - Oct 1996
Externally published	Yes

Keywords

Calcium channels
Exocytosis
Synaptic transmission

ASJC Scopus subject areas

Neuroscience(all)

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10.1006/smns.1996.0040

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title = "Calcium dependence of neurotransmitter release",

abstract = "Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca2+] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca2+] in this microdomain, together with the fast Kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.",

keywords = "Calcium channels, Exocytosis, Synaptic transmission",

author = "Gary Matthews and Henriquevon Gersdorff",

note = "Funding Information: We thank Ruth Heidelberger, Steve Mennerick, Erwin Neher and David Zenisek for useful discussions. Supported by NIH grant EY03821 (GM), NRSA Postdoctoral Fellowship EY06506 (HvG), and by a Research Award from the Alexander von Humboldt Stiftung (GM).",

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AU - Matthews, Gary

AU - Gersdorff, Henriquevon

N1 - Funding Information: We thank Ruth Heidelberger, Steve Mennerick, Erwin Neher and David Zenisek for useful discussions. Supported by NIH grant EY03821 (GM), NRSA Postdoctoral Fellowship EY06506 (HvG), and by a Research Award from the Alexander von Humboldt Stiftung (GM).

PY - 1996/10

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N2 - Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca2+] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca2+] in this microdomain, together with the fast Kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.

AB - Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca2+] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca2+] in this microdomain, together with the fast Kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.

KW - Calcium channels

KW - Exocytosis

KW - Synaptic transmission

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DO - 10.1006/smns.1996.0040

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EP - 334

JO - Seminars in the Neurosciences

JF - Seminars in the Neurosciences

IS - 5

ER -

Calcium dependence of neurotransmitter release

Abstract

Keywords

ASJC Scopus subject areas

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