Calcium dependence of neurotransmitter release

Gary Matthews, Henriquevon Gersdorff

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca2+] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca2+] in this microdomain, together with the fast Kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.

Original languageEnglish (US)
Pages (from-to)329-334
Number of pages6
JournalSeminars in the Neurosciences
Volume8
Issue number5
DOIs
StatePublished - Oct 1996

Keywords

  • Calcium channels
  • Exocytosis
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)

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