Abstract
The complex mechanism of intracellular transport is regulated by free calcium in different manners. Calcium binding proteins regulate several aspects of the vesicle fusion mechanism mediated by NSF (N-ethylmaleimide sensitive fusion factor). At least in some regulated exocytosis, calcium-binding proteins are the trigger for fusion downstream of NSF. Still, calcium-binding proteins, such as annexins, may be part of a different fusion mechanism mediating some specific transport steps or working in parallel to the NSF-dependent fusion process. Calcium is not the only ion necessary for the function of factors involved in vesicular transport. A zinc requirement has been also proposed. One of the zinc-dependent factors is probably a protein with a cysteine-rich region that coordinates zinc and binds phorbolesters. Although protein kinase C is the more prominent family of proteins carrying this domain, the factor necessary for transport does not appear to function as a kinase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 339-342 |
| Number of pages | 4 |
| Journal | Biocell |
| Volume | 20 |
| Issue number | 3 |
| State | Published - Dec 1 1996 |
| Externally published | Yes |
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Keywords
- Annexin
- Calcium
- Endocytosis
- Protein kinase C
- Zinc
ASJC Scopus subject areas
- Cell Biology
Cite this
Calcium- and zinc-binding proteins in intracellular transport. / Aballay, Alejandro; Arenas, Graciela Nora; Mayorga, Luis S.
In: Biocell, Vol. 20, No. 3, 01.12.1996, p. 339-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium- and zinc-binding proteins in intracellular transport
AU - Aballay, Alejandro
AU - Arenas, Graciela Nora
AU - Mayorga, Luis S.
PY - 1996/12/1
Y1 - 1996/12/1
N2 - The complex mechanism of intracellular transport is regulated by free calcium in different manners. Calcium binding proteins regulate several aspects of the vesicle fusion mechanism mediated by NSF (N-ethylmaleimide sensitive fusion factor). At least in some regulated exocytosis, calcium-binding proteins are the trigger for fusion downstream of NSF. Still, calcium-binding proteins, such as annexins, may be part of a different fusion mechanism mediating some specific transport steps or working in parallel to the NSF-dependent fusion process. Calcium is not the only ion necessary for the function of factors involved in vesicular transport. A zinc requirement has been also proposed. One of the zinc-dependent factors is probably a protein with a cysteine-rich region that coordinates zinc and binds phorbolesters. Although protein kinase C is the more prominent family of proteins carrying this domain, the factor necessary for transport does not appear to function as a kinase.
AB - The complex mechanism of intracellular transport is regulated by free calcium in different manners. Calcium binding proteins regulate several aspects of the vesicle fusion mechanism mediated by NSF (N-ethylmaleimide sensitive fusion factor). At least in some regulated exocytosis, calcium-binding proteins are the trigger for fusion downstream of NSF. Still, calcium-binding proteins, such as annexins, may be part of a different fusion mechanism mediating some specific transport steps or working in parallel to the NSF-dependent fusion process. Calcium is not the only ion necessary for the function of factors involved in vesicular transport. A zinc requirement has been also proposed. One of the zinc-dependent factors is probably a protein with a cysteine-rich region that coordinates zinc and binds phorbolesters. Although protein kinase C is the more prominent family of proteins carrying this domain, the factor necessary for transport does not appear to function as a kinase.
KW - Annexin
KW - Calcium
KW - Endocytosis
KW - Protein kinase C
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=0030345316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030345316&partnerID=8YFLogxK
M3 - Article
C2 - 9031603
AN - SCOPUS:0030345316
VL - 20
SP - 339
EP - 342
JO - Biocell
JF - Biocell
SN - 0327-9545
IS - 3
ER -