Calcium and cholecalciferol

Effects of small supplements in normal men

Eric Orwoll, R. M. Weigel, S. K. Oviatt, M. R. McClung, L. J. Deftos

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of small calcium and vitamin D supplements on mineral metabolism in normal persons is unclear. To investigate the biochemical response to these medications, we administered 1000 mg Ca and 25 μg cholecalciferol per day or a placebo to 92 normal men for 1 y. The Ca and cholecalciferol were tolerated well. 25-Hydroxycholecalciferol [25-(OH)D] and 24,25-dihydroxycholecalciferol [24,25-(OH)2D] levels rose in treated subjects; there was no definite change in 1,25-(OH)2D concentrations. The average difference in 25-(OH)D levels between treated and untreated subjects was 30 nmol/L at 1 y. Fasting serum Ca, alkaline phosphatase, creatinine, and parathyroid hormone levels and the fasting urinary excretion of Ca, phosphorus and cAMP, were not affected. However, 24-h urinary Ca excretion was higher in the supplemented group (3.5 ± 1.9 vs 4.7 ± 1.7 mmol/d, p = 0.006). Serum P concentrations were slightly higher in the supplemented group at 1 y. In normal men small calcium and cholecalciferol supplements are safe, provide adequate vitamin D nutrition and apparently increase net gastrointestinal Ca absorption.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Volume48
Issue number1
StatePublished - 1988

Fingerprint

cholecalciferol
Cholecalciferol
vitamin D
Calcium
calcium
Vitamin D
fasting
24,25-dihydroxycholecalciferol
Fasting
24,25-Dihydroxyvitamin D 3
excretion
mineral metabolism
25-hydroxycholecalciferol
Calcifediol
parathyroid hormone
Parathyroid Hormone
Serum
creatinine
Phosphorus
drug therapy

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Orwoll, E., Weigel, R. M., Oviatt, S. K., McClung, M. R., & Deftos, L. J. (1988). Calcium and cholecalciferol: Effects of small supplements in normal men. American Journal of Clinical Nutrition, 48(1), 127-130.

Calcium and cholecalciferol : Effects of small supplements in normal men. / Orwoll, Eric; Weigel, R. M.; Oviatt, S. K.; McClung, M. R.; Deftos, L. J.

In: American Journal of Clinical Nutrition, Vol. 48, No. 1, 1988, p. 127-130.

Research output: Contribution to journalArticle

Orwoll, E, Weigel, RM, Oviatt, SK, McClung, MR & Deftos, LJ 1988, 'Calcium and cholecalciferol: Effects of small supplements in normal men', American Journal of Clinical Nutrition, vol. 48, no. 1, pp. 127-130.
Orwoll, Eric ; Weigel, R. M. ; Oviatt, S. K. ; McClung, M. R. ; Deftos, L. J. / Calcium and cholecalciferol : Effects of small supplements in normal men. In: American Journal of Clinical Nutrition. 1988 ; Vol. 48, No. 1. pp. 127-130.
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