Calcium and cardiac electrophysiology. Some experimental considerations

M. Morad, James Maylie

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Electrophysiologic experiments in cardiac tissue suggest that Ca2+ is involved in generation of the action potential, the pacemaker potential, and conduction of the slow wave of depolarization. For instance, removal of Ca2+ inhibits the slow inward current and prolongs the action potential and suppresses the slow diastolic depolarization. Divalant cations Mn2+, Co2+, Cd2+, Mg2+, block the slow inward current and suppress pacemaker activity, but shorten the action potential. Ni2+ specifically blocks the slow inward current and prolongs the action potential. Ca2+ also plays a central role in generation of diastolic depolarization. Cd2+ inhibits the diastolic depolarization and the upstoke of the action potential in SA nodal cells, while blocking the time-dependent inward current in the pacemaker potential range and the time-dependent outward current. A variety of molecular transport systems ranging from the Ca-channel to a Ca2+-Na+ or Ca2+-K+ exchanges to Ca2+-induced activation of the K+ current have been postulated to explain the effects of Ca2+ on cardiac electrophysiologic processes.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalChest
Volume78
Issue number1 SUPPL.
StatePublished - 1980
Externally publishedYes

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Cardiac Electrophysiology
Action Potentials
Calcium
Cations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Calcium and cardiac electrophysiology. Some experimental considerations. / Morad, M.; Maylie, James.

In: Chest, Vol. 78, No. 1 SUPPL., 1980, p. 166-173.

Research output: Contribution to journalArticle

Morad, M. ; Maylie, James. / Calcium and cardiac electrophysiology. Some experimental considerations. In: Chest. 1980 ; Vol. 78, No. 1 SUPPL. pp. 166-173.
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