Calcium-activated potassium channels

Cecilia Vergara, Ramon Latorre, Neil V. Marrion, John Adelman

Research output: Contribution to journalArticle

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Abstract

Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and calcium modulated. Structurally, BK channels have been shown to possess an extracellular amino-terminal domain, different from other potassium channels. Domains and residues involved in calcium-gating, and perhaps calcium binding itself, have been identified. For small- and intermediate-conductance calcium-activated potassium channels, SK and IK channels, clones have only recently become available, and they show that SK channels are a distinct subfamily of potassium channels. The biophysical properties of SK channels demonstrate that kinetic differences between apamin-sensitive and apamin-insensitive slow after hyperpolarizations are not attributable to intrinsic gating differences between the two subtypes. Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume8
Issue number3
DOIs
StatePublished - Jun 1998

Fingerprint

Large-Conductance Calcium-Activated Potassium Channels
Calcium-Activated Potassium Channels
Apamin
Potassium Channels
Calcium
Intermediate-Conductance Calcium-Activated Potassium Channels
Small-Conductance Calcium-Activated Potassium Channels
Myotonic Dystrophy
Muscular Dystrophies
Sickle Cell Anemia
Clone Cells
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. (1998). Calcium-activated potassium channels. Current Opinion in Neurobiology, 8(3), 321-329. https://doi.org/10.1016/S0959-4388(98)80056-1

Calcium-activated potassium channels. / Vergara, Cecilia; Latorre, Ramon; Marrion, Neil V.; Adelman, John.

In: Current Opinion in Neurobiology, Vol. 8, No. 3, 06.1998, p. 321-329.

Research output: Contribution to journalArticle

Vergara, C, Latorre, R, Marrion, NV & Adelman, J 1998, 'Calcium-activated potassium channels', Current Opinion in Neurobiology, vol. 8, no. 3, pp. 321-329. https://doi.org/10.1016/S0959-4388(98)80056-1
Vergara, Cecilia ; Latorre, Ramon ; Marrion, Neil V. ; Adelman, John. / Calcium-activated potassium channels. In: Current Opinion in Neurobiology. 1998 ; Vol. 8, No. 3. pp. 321-329.
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