Calcium absorption in Nigerian children with rickets.

Mariaelisa Graff, Tom D. Thacher, Philip R. Fischer, Diane Stadler, Sunday D. Pam, John M. Pettifor, Christian O. Isichei, Steven A. Abrams

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

BACKGROUND: Nutritional rickets is common in Nigerian children and responds to calcium supplementation. Low dietary calcium intakes are also common in Nigerian children with and without rickets. OBJECTIVE: The objective was to assess intestinal calcium absorption in Nigerian children with rickets. DESIGN: Calcium absorption was assessed in 15 children with active rickets (2-8 y of age) and in 15 age- and sex-matched children without rickets by using a dual-tracer stable-isotope method. The children with rickets were supplemented with calcium for 6 mo; calcium absorption was reevaluated 12 mo after the baseline study. Fractional calcium absorption could be determined in 10 children with rickets and in 10 children without rickets. RESULTS: The children with and without rickets had dietary calcium intakes of approximately 200 mg/d. Compared with the control children, the children with rickets had lower serum 25-hydroxyvitamin D and calcium concentrations and greater 1,25-dihydroxyvitamin D and parathyroid hormone concentrations. In fact, there were 15 rachitic and 15 control children in the study. Mean (+/-SD) fractional calcium absorption did not differ between those with (61 +/- 20%) and without (63 +/- 13%) rickets (P = 0.47). Calcium absorption was not associated with serum concentrations of calcium, alkaline phosphatase, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or parathyroid hormone. Mean fractional calcium absorption was significantly greater after (81 +/- 10%) than before (61 +/- 20%) calcium supplementation for the treatment of rickets (P = 0.035). CONCLUSIONS: In Nigerian children with rickets, the capacity to absorb calcium is not impaired; however, fractional calcium absorption increases after the resolution of active disease. Calcium absorption may be inadequate to meet the skeletal demands of children with rickets during the active phase of the disease, despite being similar to that of control children.

Original languageEnglish (US)
Pages (from-to)1415-1421
Number of pages7
JournalThe American journal of clinical nutrition
Volume80
Issue number5
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

rickets
Rickets
Calcium
calcium
Dietary Calcium
parathyroid hormone
Parathyroid Hormone
Intestinal Absorption
Serum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Graff, M., Thacher, T. D., Fischer, P. R., Stadler, D., Pam, S. D., Pettifor, J. M., ... Abrams, S. A. (2004). Calcium absorption in Nigerian children with rickets. The American journal of clinical nutrition, 80(5), 1415-1421.

Calcium absorption in Nigerian children with rickets. / Graff, Mariaelisa; Thacher, Tom D.; Fischer, Philip R.; Stadler, Diane; Pam, Sunday D.; Pettifor, John M.; Isichei, Christian O.; Abrams, Steven A.

In: The American journal of clinical nutrition, Vol. 80, No. 5, 11.2004, p. 1415-1421.

Research output: Contribution to journalArticle

Graff, M, Thacher, TD, Fischer, PR, Stadler, D, Pam, SD, Pettifor, JM, Isichei, CO & Abrams, SA 2004, 'Calcium absorption in Nigerian children with rickets.', The American journal of clinical nutrition, vol. 80, no. 5, pp. 1415-1421.
Graff M, Thacher TD, Fischer PR, Stadler D, Pam SD, Pettifor JM et al. Calcium absorption in Nigerian children with rickets. The American journal of clinical nutrition. 2004 Nov;80(5):1415-1421.
Graff, Mariaelisa ; Thacher, Tom D. ; Fischer, Philip R. ; Stadler, Diane ; Pam, Sunday D. ; Pettifor, John M. ; Isichei, Christian O. ; Abrams, Steven A. / Calcium absorption in Nigerian children with rickets. In: The American journal of clinical nutrition. 2004 ; Vol. 80, No. 5. pp. 1415-1421.
@article{8bcdfb1961394408b45a4a3ac7ab6579,
title = "Calcium absorption in Nigerian children with rickets.",
abstract = "BACKGROUND: Nutritional rickets is common in Nigerian children and responds to calcium supplementation. Low dietary calcium intakes are also common in Nigerian children with and without rickets. OBJECTIVE: The objective was to assess intestinal calcium absorption in Nigerian children with rickets. DESIGN: Calcium absorption was assessed in 15 children with active rickets (2-8 y of age) and in 15 age- and sex-matched children without rickets by using a dual-tracer stable-isotope method. The children with rickets were supplemented with calcium for 6 mo; calcium absorption was reevaluated 12 mo after the baseline study. Fractional calcium absorption could be determined in 10 children with rickets and in 10 children without rickets. RESULTS: The children with and without rickets had dietary calcium intakes of approximately 200 mg/d. Compared with the control children, the children with rickets had lower serum 25-hydroxyvitamin D and calcium concentrations and greater 1,25-dihydroxyvitamin D and parathyroid hormone concentrations. In fact, there were 15 rachitic and 15 control children in the study. Mean (+/-SD) fractional calcium absorption did not differ between those with (61 +/- 20{\%}) and without (63 +/- 13{\%}) rickets (P = 0.47). Calcium absorption was not associated with serum concentrations of calcium, alkaline phosphatase, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or parathyroid hormone. Mean fractional calcium absorption was significantly greater after (81 +/- 10{\%}) than before (61 +/- 20{\%}) calcium supplementation for the treatment of rickets (P = 0.035). CONCLUSIONS: In Nigerian children with rickets, the capacity to absorb calcium is not impaired; however, fractional calcium absorption increases after the resolution of active disease. Calcium absorption may be inadequate to meet the skeletal demands of children with rickets during the active phase of the disease, despite being similar to that of control children.",
author = "Mariaelisa Graff and Thacher, {Tom D.} and Fischer, {Philip R.} and Diane Stadler and Pam, {Sunday D.} and Pettifor, {John M.} and Isichei, {Christian O.} and Abrams, {Steven A.}",
year = "2004",
month = "11",
language = "English (US)",
volume = "80",
pages = "1415--1421",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Calcium absorption in Nigerian children with rickets.

AU - Graff, Mariaelisa

AU - Thacher, Tom D.

AU - Fischer, Philip R.

AU - Stadler, Diane

AU - Pam, Sunday D.

AU - Pettifor, John M.

AU - Isichei, Christian O.

AU - Abrams, Steven A.

PY - 2004/11

Y1 - 2004/11

N2 - BACKGROUND: Nutritional rickets is common in Nigerian children and responds to calcium supplementation. Low dietary calcium intakes are also common in Nigerian children with and without rickets. OBJECTIVE: The objective was to assess intestinal calcium absorption in Nigerian children with rickets. DESIGN: Calcium absorption was assessed in 15 children with active rickets (2-8 y of age) and in 15 age- and sex-matched children without rickets by using a dual-tracer stable-isotope method. The children with rickets were supplemented with calcium for 6 mo; calcium absorption was reevaluated 12 mo after the baseline study. Fractional calcium absorption could be determined in 10 children with rickets and in 10 children without rickets. RESULTS: The children with and without rickets had dietary calcium intakes of approximately 200 mg/d. Compared with the control children, the children with rickets had lower serum 25-hydroxyvitamin D and calcium concentrations and greater 1,25-dihydroxyvitamin D and parathyroid hormone concentrations. In fact, there were 15 rachitic and 15 control children in the study. Mean (+/-SD) fractional calcium absorption did not differ between those with (61 +/- 20%) and without (63 +/- 13%) rickets (P = 0.47). Calcium absorption was not associated with serum concentrations of calcium, alkaline phosphatase, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or parathyroid hormone. Mean fractional calcium absorption was significantly greater after (81 +/- 10%) than before (61 +/- 20%) calcium supplementation for the treatment of rickets (P = 0.035). CONCLUSIONS: In Nigerian children with rickets, the capacity to absorb calcium is not impaired; however, fractional calcium absorption increases after the resolution of active disease. Calcium absorption may be inadequate to meet the skeletal demands of children with rickets during the active phase of the disease, despite being similar to that of control children.

AB - BACKGROUND: Nutritional rickets is common in Nigerian children and responds to calcium supplementation. Low dietary calcium intakes are also common in Nigerian children with and without rickets. OBJECTIVE: The objective was to assess intestinal calcium absorption in Nigerian children with rickets. DESIGN: Calcium absorption was assessed in 15 children with active rickets (2-8 y of age) and in 15 age- and sex-matched children without rickets by using a dual-tracer stable-isotope method. The children with rickets were supplemented with calcium for 6 mo; calcium absorption was reevaluated 12 mo after the baseline study. Fractional calcium absorption could be determined in 10 children with rickets and in 10 children without rickets. RESULTS: The children with and without rickets had dietary calcium intakes of approximately 200 mg/d. Compared with the control children, the children with rickets had lower serum 25-hydroxyvitamin D and calcium concentrations and greater 1,25-dihydroxyvitamin D and parathyroid hormone concentrations. In fact, there were 15 rachitic and 15 control children in the study. Mean (+/-SD) fractional calcium absorption did not differ between those with (61 +/- 20%) and without (63 +/- 13%) rickets (P = 0.47). Calcium absorption was not associated with serum concentrations of calcium, alkaline phosphatase, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or parathyroid hormone. Mean fractional calcium absorption was significantly greater after (81 +/- 10%) than before (61 +/- 20%) calcium supplementation for the treatment of rickets (P = 0.035). CONCLUSIONS: In Nigerian children with rickets, the capacity to absorb calcium is not impaired; however, fractional calcium absorption increases after the resolution of active disease. Calcium absorption may be inadequate to meet the skeletal demands of children with rickets during the active phase of the disease, despite being similar to that of control children.

UR - http://www.scopus.com/inward/record.url?scp=16544367414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16544367414&partnerID=8YFLogxK

M3 - Article

VL - 80

SP - 1415

EP - 1421

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -