Calcitriol and vitamin d analogs

Ana R. Jensen, Russell Z. Szmulewitz, Tomasz M. Beer, Edwin M. Posadas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Calcitriol (1,25-dihydroxycholecaliferol) is a synthetic analog of vitamin D that is physiologically active in absorption of calcium from the gastrointestinal tract. Recent clinical and laboratory developments have fueled enthusiasm for studying the role of vitamin D and its relationship to oncogenesis and malignant progression. There are epidemiological data pointing toward a link between vitamin D and prostate cancer as well as preclinical and clinical data linking antineoplastic activity of vitamin D receptor ligands with prostate cancer. As such, efforts have been geared toward the development of vitamin D receptor ligand-based therapy for early and advanced prostate cancer. In this chapter we will discuss the historic and current thoughts on the role that vitamin D may play in prostate cancer risk and treatment.

Original languageEnglish (US)
Title of host publicationDrug Management of Prostate Cancer
PublisherSpringer New York
Pages287-302
Number of pages16
ISBN (Print)9781603278317
DOIs
StatePublished - Dec 1 2010

Keywords

  • Calcitriol
  • Vitamin D
  • Vitamin D receptor

ASJC Scopus subject areas

  • Medicine(all)

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