Abstract
Calcitriol (1,25-dihydroxycholecaliferol) is a synthetic analog of vitamin D that is physiologically active in absorption of calcium from the gastrointestinal tract. Recent clinical and laboratory developments have fueled enthusiasm for studying the role of vitamin D and its relationship to oncogenesis and malignant progression. There are epidemiological data pointing toward a link between vitamin D and prostate cancer as well as preclinical and clinical data linking antineoplastic activity of vitamin D receptor ligands with prostate cancer. As such, efforts have been geared toward the development of vitamin D receptor ligand-based therapy for early and advanced prostate cancer. In this chapter we will discuss the historic and current thoughts on the role that vitamin D may play in prostate cancer risk and treatment.
Original language | English (US) |
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Title of host publication | Drug Management of Prostate Cancer |
Publisher | Springer New York |
Pages | 287-302 |
Number of pages | 16 |
ISBN (Print) | 9781603278317 |
DOIs | |
State | Published - 2010 |
Keywords
- Calcitriol
- Vitamin D
- Vitamin D receptor
ASJC Scopus subject areas
- General Medicine