Calcitriol and vitamin d analogs

Ana R. Jensen, Russell Z. Szmulewitz, Tomasz M. Beer, Edwin M. Posadas

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Calcitriol (1,25-dihydroxycholecaliferol) is a synthetic analog of vitamin D that is physiologically active in absorption of calcium from the gastrointestinal tract. Recent clinical and laboratory developments have fueled enthusiasm for studying the role of vitamin D and its relationship to oncogenesis and malignant progression. There are epidemiological data pointing toward a link between vitamin D and prostate cancer as well as preclinical and clinical data linking antineoplastic activity of vitamin D receptor ligands with prostate cancer. As such, efforts have been geared toward the development of vitamin D receptor ligand-based therapy for early and advanced prostate cancer. In this chapter we will discuss the historic and current thoughts on the role that vitamin D may play in prostate cancer risk and treatment.

    Original languageEnglish (US)
    Title of host publicationDrug Management of Prostate Cancer
    PublisherSpringer New York
    Pages287-302
    Number of pages16
    ISBN (Print)9781603278317
    DOIs
    StatePublished - Dec 1 2010

    Keywords

    • Calcitriol
    • Vitamin D
    • Vitamin D receptor

    ASJC Scopus subject areas

    • Medicine(all)

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  • Cite this

    Jensen, A. R., Szmulewitz, R. Z., Beer, T. M., & Posadas, E. M. (2010). Calcitriol and vitamin d analogs. In Drug Management of Prostate Cancer (pp. 287-302). Springer New York. https://doi.org/10.1007/978-1-60327-829-4_26