Caged lipids for subcellular manipulation

Scotland Farley; Aurélien Laguerre; Carsten Schultz

doi:10.1016/j.cbpa.2021.04.012

Caged lipids for subcellular manipulation

Scotland Farley, Aurélien Laguerre, Carsten Schultz

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

We present recently developed strategies to manipulate lipid levels in live cells by light. We focus on photoremovable protecting groups that lead to subcellular restricted localization and activation and discuss alternative techniques. We emphasize the development of organelle targeting of caged lipids and discuss recent advances in chromatic orthogonality of caging groups for future applications.

Original language	English (US)
Pages (from-to)	42-48
Number of pages	7
Journal	Current Opinion in Chemical Biology
Volume	65
DOIs	https://doi.org/10.1016/j.cbpa.2021.04.012
State	Published - Dec 2021
Externally published	Yes

Keywords

Fluorescence
Lipid transport
Photoactivation
Signaling

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/j.cbpa.2021.04.012

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title = "Caged lipids for subcellular manipulation",

abstract = "We present recently developed strategies to manipulate lipid levels in live cells by light. We focus on photoremovable protecting groups that lead to subcellular restricted localization and activation and discuss alternative techniques. We emphasize the development of organelle targeting of caged lipids and discuss recent advances in chromatic orthogonality of caging groups for future applications.",

keywords = "Fluorescence, Lipid transport, Photoactivation, Signaling",

author = "Scotland Farley and Aur{\'e}lien Laguerre and Carsten Schultz",

note = "Funding Information: S.F., A.L., and C.S. acknowledge financial support by OHSU . C.S. is grateful for funding by the NIH ( R01GM127631 and R01 AI141549 ) and TRR186, funded by the German Research Council ( DFG ). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = dec,

doi = "10.1016/j.cbpa.2021.04.012",

language = "English (US)",

volume = "65",

pages = "42--48",

journal = "Current Opinion in Chemical Biology",

issn = "1367-5931",

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TY - JOUR

T1 - Caged lipids for subcellular manipulation

AU - Farley, Scotland

AU - Laguerre, Aurélien

AU - Schultz, Carsten

N1 - Funding Information: S.F., A.L., and C.S. acknowledge financial support by OHSU . C.S. is grateful for funding by the NIH ( R01GM127631 and R01 AI141549 ) and TRR186, funded by the German Research Council ( DFG ). Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/12

Y1 - 2021/12

N2 - We present recently developed strategies to manipulate lipid levels in live cells by light. We focus on photoremovable protecting groups that lead to subcellular restricted localization and activation and discuss alternative techniques. We emphasize the development of organelle targeting of caged lipids and discuss recent advances in chromatic orthogonality of caging groups for future applications.

AB - We present recently developed strategies to manipulate lipid levels in live cells by light. We focus on photoremovable protecting groups that lead to subcellular restricted localization and activation and discuss alternative techniques. We emphasize the development of organelle targeting of caged lipids and discuss recent advances in chromatic orthogonality of caging groups for future applications.

KW - Fluorescence

KW - Lipid transport

KW - Photoactivation

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=85107643863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85107643863&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2021.04.012

DO - 10.1016/j.cbpa.2021.04.012

M3 - Review article

C2 - 34119744

AN - SCOPUS:85107643863

SN - 1367-5931

VL - 65

SP - 42

EP - 48

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

ER -

Caged lipids for subcellular manipulation

Abstract

Keywords

ASJC Scopus subject areas

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