Caffeoylquinic acids in centella asiatica reverse cognitive deficits in male 5XFAD Alzheimer’s disease model mice

Donald G. Matthews, Maya Caruso, Armando Alcazar Magana, Kirsten M. Wright, Claudia S. Maier, Jan F. Stevens, Nora E. Gray, Joseph F. Quinn, Amala Soumyanath

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Centella asiatica (CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA’s ability to improve learning and memory. This study evaluated the contribution of CA’s triterpenes (TT), widely considered its active compounds, and caffeoylquinic acids (CQA) to the cognitive effects of CA water extract (CAW) in 5XFAD mice, a model of Alzheimer’s disease. 5XFAD mice were fed a control diet alone, or one containing 1% CAW or compound groups (TT, CQA, or TT + CQA) equivalent to their content in 1% CAW. Wild-type (WT) littermates received the control diet. Conditioned fear response (CFR) was evaluated after 4.5 weeks. Female 5XFAD controls showed no deficit in CFR compared to WT females, nor any effects from treatment. In males, CFR of 5XFAD controls was attenuated compared to WT littermates (p = 0.005). 5XFAD males receiving CQA or TT + CQA had significantly improved CFR (p < 0.05) compared to 5XFAD male controls. CFR did not differ between 5XFAD males receiving treatment diets and WT males. These data confirm a role for CQA in CAW’s cognitive effects.

Original languageEnglish (US)
Article number3488
Pages (from-to)1-9
Number of pages9
Issue number11
StatePublished - Nov 2020


  • 5XFAD
  • Caffeoylquinic acids
  • Centella asiatica
  • Conditioned fear response
  • Family Apiaceae
  • Triterpenes

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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