Ca2+ influx and neurotransmitter release at ribbon synapses

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Ca2+ influx through voltage-gated Ca2+ channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribbon synapses exhibit SNARE-mediated exocytosis, clathrin-mediated endocytosis, and short-term plasticity. However, unlike non-ribbon synapses, voltage-gated L-type Ca2+ channel opening at ribbon synapses triggers a form of multiquantal release that can be highly synchronous. Furthermore, ribbon synapses appear to be specialized for fast and high throughput exocytosis controlled by graded membrane potential changes. Here we will discuss some of the basic aspects of synaptic transmission at different types of ribbon synapses, and we will emphasize recent evidence that auditory and retinal ribbon synapses have marked differences. This will lead us to suggest that ribbon synapses are specialized for particular operating ranges and frequencies of stimulation. We propose that different types of ribbon synapses transfer diverse rates of sensory information by expressing a particular repertoire of critical components, and by placing them at precise and strategic locations, so that a continuous supply of primed vesicles and Ca2+ influx leads to fast, accurate, and ongoing exocytosis.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalCell Calcium
Volume52
Issue number3-4
DOIs
StatePublished - Sep 2012

Fingerprint

Synapses
Neurotransmitter Agents
Exocytosis
SNARE Proteins
Clathrin
Presynaptic Terminals
Sensory Receptor Cells
Endocytosis
Synaptic Transmission
Organelles
Membrane Potentials
Electrons

Keywords

  • Calcium channels
  • Calcium microdomains
  • Exocytosis
  • Ribbon synapses
  • Short-term plasticity
  • Synaptic transmission
  • Transmitter release

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Ca2+ influx and neurotransmitter release at ribbon synapses. / Cho, Soyoun; Von Gersdorff, Henrique.

In: Cell Calcium, Vol. 52, No. 3-4, 09.2012, p. 208-216.

Research output: Contribution to journalArticle

@article{3cbe2b643d03467284e063f6c38a0ebe,
title = "Ca2+ influx and neurotransmitter release at ribbon synapses",
abstract = "Ca2+ influx through voltage-gated Ca2+ channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribbon synapses exhibit SNARE-mediated exocytosis, clathrin-mediated endocytosis, and short-term plasticity. However, unlike non-ribbon synapses, voltage-gated L-type Ca2+ channel opening at ribbon synapses triggers a form of multiquantal release that can be highly synchronous. Furthermore, ribbon synapses appear to be specialized for fast and high throughput exocytosis controlled by graded membrane potential changes. Here we will discuss some of the basic aspects of synaptic transmission at different types of ribbon synapses, and we will emphasize recent evidence that auditory and retinal ribbon synapses have marked differences. This will lead us to suggest that ribbon synapses are specialized for particular operating ranges and frequencies of stimulation. We propose that different types of ribbon synapses transfer diverse rates of sensory information by expressing a particular repertoire of critical components, and by placing them at precise and strategic locations, so that a continuous supply of primed vesicles and Ca2+ influx leads to fast, accurate, and ongoing exocytosis.",
keywords = "Calcium channels, Calcium microdomains, Exocytosis, Ribbon synapses, Short-term plasticity, Synaptic transmission, Transmitter release",
author = "Soyoun Cho and {Von Gersdorff}, Henrique",
year = "2012",
month = "9",
doi = "10.1016/j.ceca.2012.06.004",
language = "English (US)",
volume = "52",
pages = "208--216",
journal = "Cell Calcium",
issn = "0143-4160",
publisher = "Churchill Livingstone",
number = "3-4",

}

TY - JOUR

T1 - Ca2+ influx and neurotransmitter release at ribbon synapses

AU - Cho, Soyoun

AU - Von Gersdorff, Henrique

PY - 2012/9

Y1 - 2012/9

N2 - Ca2+ influx through voltage-gated Ca2+ channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribbon synapses exhibit SNARE-mediated exocytosis, clathrin-mediated endocytosis, and short-term plasticity. However, unlike non-ribbon synapses, voltage-gated L-type Ca2+ channel opening at ribbon synapses triggers a form of multiquantal release that can be highly synchronous. Furthermore, ribbon synapses appear to be specialized for fast and high throughput exocytosis controlled by graded membrane potential changes. Here we will discuss some of the basic aspects of synaptic transmission at different types of ribbon synapses, and we will emphasize recent evidence that auditory and retinal ribbon synapses have marked differences. This will lead us to suggest that ribbon synapses are specialized for particular operating ranges and frequencies of stimulation. We propose that different types of ribbon synapses transfer diverse rates of sensory information by expressing a particular repertoire of critical components, and by placing them at precise and strategic locations, so that a continuous supply of primed vesicles and Ca2+ influx leads to fast, accurate, and ongoing exocytosis.

AB - Ca2+ influx through voltage-gated Ca2+ channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribbon synapses exhibit SNARE-mediated exocytosis, clathrin-mediated endocytosis, and short-term plasticity. However, unlike non-ribbon synapses, voltage-gated L-type Ca2+ channel opening at ribbon synapses triggers a form of multiquantal release that can be highly synchronous. Furthermore, ribbon synapses appear to be specialized for fast and high throughput exocytosis controlled by graded membrane potential changes. Here we will discuss some of the basic aspects of synaptic transmission at different types of ribbon synapses, and we will emphasize recent evidence that auditory and retinal ribbon synapses have marked differences. This will lead us to suggest that ribbon synapses are specialized for particular operating ranges and frequencies of stimulation. We propose that different types of ribbon synapses transfer diverse rates of sensory information by expressing a particular repertoire of critical components, and by placing them at precise and strategic locations, so that a continuous supply of primed vesicles and Ca2+ influx leads to fast, accurate, and ongoing exocytosis.

KW - Calcium channels

KW - Calcium microdomains

KW - Exocytosis

KW - Ribbon synapses

KW - Short-term plasticity

KW - Synaptic transmission

KW - Transmitter release

UR - http://www.scopus.com/inward/record.url?scp=84865763919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865763919&partnerID=8YFLogxK

U2 - 10.1016/j.ceca.2012.06.004

DO - 10.1016/j.ceca.2012.06.004

M3 - Article

VL - 52

SP - 208

EP - 216

JO - Cell Calcium

JF - Cell Calcium

SN - 0143-4160

IS - 3-4

ER -