C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: Eesults from the ASCENT trial

Tomasz M. Beer, Alshad S. Lalani, Stella Lee, Motomi Mori, Kristine M. Eilers, John G. Curd, W. David Henner, Christopher W. Ryan, Peter Venner, J. Dean Ruether, Kim N. Chi

    Research output: Contribution to journalArticlepeer-review

    90 Scopus citations

    Abstract

    BACKGROUND. Studies of cancer risk and molecular carcinogenesis suggest a role for inflammation in cancer development and progression. The authors sought to determine whether specific blood proteins associated with inflammation predict for outcomes in men with metastatic androgen-independent prostate cancer (AIPC) who are initiating docetaxel-based chemotherapy. METHODS. Baseline plasma samples were stored (-80°C) from 160 of 250 patients enrolled in the AIPC Study of Calcitriol ENhancing Taxotere (ASCENT) trial, a randomized, placebo-controlled trial comparing weekly docetaxel plus high-dose calcitriol with weekly docetaxel. Multiplex immunoassays measured 16 cytokine, chemokine, cardiovascular, or inflammatory markers. The Cox proportional hazards model was used to assess associations between baseline biomarkers, clinical characteristics, and survival. Logistic regression was used for analyses of associations with prostate-specific antigen (PSA) decline. RESULTS. C-reactive protein (CRP) was found to be significantly predictive of a shorter overall survival (hazards ratio [HR] of 1.41 for each natural logarithm [In] [CRP] increase; 95% confidence interval [95% CI], 1.20-1.65 [P < .0001]). When CRP (continuous) was entered into a multivariate model using 13 baseline clinical variables, only elevated CRP remained a significant predictor (P < .0001) of shorter overall survival. When categorized as normal (≤8 mg/L) or abnormal (>8 mg/L), elevated CRP was found to be a significant predictor of shorter overall survival (HR of 2.96; 95% CI, 1.52-5.77 [P = .001]), as was hemoglobin (P = .007). Elevated CRP was also associated with a lower probability of PSA decline (odds ratio of 0.74 for each In(CRP) increase; 95% CI, 0.60-0.92 [P = .007]). CONCLUSIONS. Elevated plasma CRP concentrations appear to be a strong predictor of poor survival and lower probability of PSA response to treatment in patients with AIPC who are receiving docetaxel-based therapy.

    Original languageEnglish (US)
    Pages (from-to)2377-2383
    Number of pages7
    JournalCancer
    Volume112
    Issue number11
    DOIs
    StatePublished - Jun 1 2008

    Keywords

    • C-reactive protein
    • Inflammation
    • Prognostic factors
    • Prostate cancer

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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