Butler enables rapid cloud-based analysis of thousands of human genomes

PCAWG Technical Working Group, PCAWG Consortium

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalNature biotechnology
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2020

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

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