Burst firing in dopamine neurons induced by N-methyl-D-aspartate: Role of electrogenic sodium pump

Steven W. Johnson, Vincent Seutin, R. Alan North

Research output: Contribution to journalArticle

348 Scopus citations

Abstract

Dopamine-containing neurons of the mammalian midbrain are required for normal behavior and movements. In vivo they fire action potentials in bursts, but in vitro they discharge regularly spaced action potentials. Burst firing in vitro has now been shown to be robustly induced by the glutamate agonist N-methyl-D-aspartate (NMDA) although not by the non-NMDA agonists kainate or quisqualate. The hyperpolarization between bursts of action potentials results from electrogenic sodium ion extrusion by a ouabain-sensitive pump. This mechanism of burst generation in mammalian neurons may be important in the pathophysiology of schizophrenia and Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalScience
Volume258
Issue number5082
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

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