Burst firing in dopamine neurons induced by N-methyl-D-aspartate: Role of electrogenic sodium pump

Steven Johnson, Vincent Seutin, R. Alan North

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

Dopamine-containing neurons of the mammalian midbrain are required for normal behavior and movements. In vivo they fire action potentials in bursts, but in vitro they discharge regularly spaced action potentials. Burst firing in vitro has now been shown to be robustly induced by the glutamate agonist N-methyl-D-aspartate (NMDA) although not by the non-NMDA agonists kainate or quisqualate. The hyperpolarization between bursts of action potentials results from electrogenic sodium ion extrusion by a ouabain-sensitive pump. This mechanism of burst generation in mammalian neurons may be important in the pathophysiology of schizophrenia and Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalScience
Volume258
Issue number5082
StatePublished - Oct 23 1992

Fingerprint

Sodium-Potassium-Exchanging ATPase
Dopaminergic Neurons
N-Methylaspartate
Action Potentials
Quisqualic Acid
Excitatory Amino Acid Agonists
D-Aspartic Acid
Kainic Acid
Ouabain
Mesencephalon
Parkinson Disease
Schizophrenia
Sodium
Ions
Neurons
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Burst firing in dopamine neurons induced by N-methyl-D-aspartate : Role of electrogenic sodium pump. / Johnson, Steven; Seutin, Vincent; North, R. Alan.

In: Science, Vol. 258, No. 5082, 23.10.1992, p. 665-667.

Research output: Contribution to journalArticle

Johnson, Steven ; Seutin, Vincent ; North, R. Alan. / Burst firing in dopamine neurons induced by N-methyl-D-aspartate : Role of electrogenic sodium pump. In: Science. 1992 ; Vol. 258, No. 5082. pp. 665-667.
@article{203d25e29c4d45ad8b7f282f3147ac53,
title = "Burst firing in dopamine neurons induced by N-methyl-D-aspartate: Role of electrogenic sodium pump",
abstract = "Dopamine-containing neurons of the mammalian midbrain are required for normal behavior and movements. In vivo they fire action potentials in bursts, but in vitro they discharge regularly spaced action potentials. Burst firing in vitro has now been shown to be robustly induced by the glutamate agonist N-methyl-D-aspartate (NMDA) although not by the non-NMDA agonists kainate or quisqualate. The hyperpolarization between bursts of action potentials results from electrogenic sodium ion extrusion by a ouabain-sensitive pump. This mechanism of burst generation in mammalian neurons may be important in the pathophysiology of schizophrenia and Parkinson's disease.",
author = "Steven Johnson and Vincent Seutin and North, {R. Alan}",
year = "1992",
month = "10",
day = "23",
language = "English (US)",
volume = "258",
pages = "665--667",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5082",

}

TY - JOUR

T1 - Burst firing in dopamine neurons induced by N-methyl-D-aspartate

T2 - Role of electrogenic sodium pump

AU - Johnson, Steven

AU - Seutin, Vincent

AU - North, R. Alan

PY - 1992/10/23

Y1 - 1992/10/23

N2 - Dopamine-containing neurons of the mammalian midbrain are required for normal behavior and movements. In vivo they fire action potentials in bursts, but in vitro they discharge regularly spaced action potentials. Burst firing in vitro has now been shown to be robustly induced by the glutamate agonist N-methyl-D-aspartate (NMDA) although not by the non-NMDA agonists kainate or quisqualate. The hyperpolarization between bursts of action potentials results from electrogenic sodium ion extrusion by a ouabain-sensitive pump. This mechanism of burst generation in mammalian neurons may be important in the pathophysiology of schizophrenia and Parkinson's disease.

AB - Dopamine-containing neurons of the mammalian midbrain are required for normal behavior and movements. In vivo they fire action potentials in bursts, but in vitro they discharge regularly spaced action potentials. Burst firing in vitro has now been shown to be robustly induced by the glutamate agonist N-methyl-D-aspartate (NMDA) although not by the non-NMDA agonists kainate or quisqualate. The hyperpolarization between bursts of action potentials results from electrogenic sodium ion extrusion by a ouabain-sensitive pump. This mechanism of burst generation in mammalian neurons may be important in the pathophysiology of schizophrenia and Parkinson's disease.

UR - http://www.scopus.com/inward/record.url?scp=0026460114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026460114&partnerID=8YFLogxK

M3 - Article

C2 - 1329209

AN - SCOPUS:0026460114

VL - 258

SP - 665

EP - 667

JO - Science

JF - Science

SN - 0036-8075

IS - 5082

ER -