Burden of obstructive lung disease study in Tehran

Prevalence and risk factors of chronic obstructive pulmonary disease

Hooman Sharifi, Mohammad Reza Masjedi, Habib Emami, Mostafa Ghanei, Alireza Eslaminejad, Golnar Radmand, A (Sonia) Buist

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Chronic obstructive pulmonary disease (COPD) was ranked the sixth-most common cause of death worldwide in 1990, but now it is the third-most common cause. The goal of the present study was to assess the prevalence and determine the causes and risk factors of COPD in Tehran. Materials and Methods: This study followed a stratified cluster sampling strategy with proportional allocation within strata. The target population was all non-institutionalized inhabitants, aged 18 to 40 in one group and over 40 in another who resided in Tehran in 2013. The core questionnaire was developed from pre-existing validated questionnaires that had already been used in multi-national studies. The single most important outcome measure obtained as part of this protocol was spirometry before and after the administration of 200 mg (two puffs) of salbutamol. Results: The most commonly reported respiratory symptoms were: sputum production in 291 patients (16.2%) [95% confidence interval (CI): 14.5-17.9%], chronic cough in 171 (9.5%) (95% CI: 8.2-10.9%), wheezing in 377 (21.0%) (95%CI: 19.1-22.9%) and dyspnea in 388 patients (21.6%) (95% CI: 19.7-23.5%). The overall COPD prevalence defined by the post-bronchodilator spirometric functional criteria was 9.2%. This value in men (10.1%) was higher than in women (8.5%); the prevalence was significantly higher in subjects aged over 55 years (P ≤ 0.002). The prevalence of COPD was strongly dependent on smoking status, especially in ex-smokers, and increased considerably with age. 69% of patients with COPD were non-smoker. Conclusion: The high prevalence of verified COPD, a great deal of which was undiagnosed before by a physician, highlights the necessity of raising awareness of this disease among health professionals, and use of spirometry in the primary care setting. A future cross-sectional and prospective cohort study should be performed to explore all risk factors and their impact on decline in lung function and worsening of respiratory symptoms especially in non-smokers.

Original languageEnglish (US)
Pages (from-to)572-577
Number of pages6
JournalLung India
Volume32
Issue number6
DOIs
StatePublished - Nov 1 2015

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Obstructive Lung Diseases
Chronic Obstructive Pulmonary Disease
Confidence Intervals
Spirometry
Albuterol
Health Services Needs and Demand
Bronchodilator Agents
Respiratory Sounds
Sputum
Cough
Dyspnea
Cause of Death
Primary Health Care
Cohort Studies
Smoking
Outcome Assessment (Health Care)
Prospective Studies
Physicians
Lung
Health

Keywords

  • Chronic obstructive pulmonary disease
  • Iran
  • prevalence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Burden of obstructive lung disease study in Tehran : Prevalence and risk factors of chronic obstructive pulmonary disease. / Sharifi, Hooman; Masjedi, Mohammad Reza; Emami, Habib; Ghanei, Mostafa; Eslaminejad, Alireza; Radmand, Golnar; Buist, A (Sonia).

In: Lung India, Vol. 32, No. 6, 01.11.2015, p. 572-577.

Research output: Contribution to journalArticle

Sharifi, Hooman ; Masjedi, Mohammad Reza ; Emami, Habib ; Ghanei, Mostafa ; Eslaminejad, Alireza ; Radmand, Golnar ; Buist, A (Sonia). / Burden of obstructive lung disease study in Tehran : Prevalence and risk factors of chronic obstructive pulmonary disease. In: Lung India. 2015 ; Vol. 32, No. 6. pp. 572-577.
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