Bupivacaine inhibits baroreflex control of heart rate in conscious rats

Kyoung S K Chang, Don R. Morrow, Kazuyo Kuzume, Michael Andresen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Because exposure to intravenously administered bupivacaine may alter cardiovascular reflexes, the authors examined bupivacaine actions on baroreflex control of heart rate in conscious rats. Methods: Baroreflex sensitivity (pulse interval vs. systolic blood pressure in ms/mmHg) was determined before, and 1.5 and 15.0 min after rapid intravenous administration of bupivacaine (0.5, 1.0, and 2.0 mg/kg) using heart rate changes evoked by intravenously administered phenylephrine or nitroprusside. The actions on the sympathetic and parasympathetic autonomic divisions of the baroreflex were tested in the presence of a muscarinic antagonist methyl atropine and a β-adrenergic antagonist atenolol. Results: Within seconds of injection of bupivacaine, mean arterial pressure increased and heart rate decreased in a dose-dependent manner. Baroreflex sensitivity was unaltered after administration of 0.5 mg/kg bupivacaine. In addition, 1 mg/kg bupivacaine at 1.5 min depressed phenylephrine-evoked reflex bradycardia (0.776 ± 0.325 vs. 0.543 ± 0.282 ms/mmHg, P <0.05) but had no effect on nitroprusside-induced tachycardia. Bupivacaine (2 mg/kg), however, depressed reflex bradycardia and tachycardia (phenylephrine, 0.751 ± 0.318 vs. 0.451 ± 0.265; nitroprusside, 0.839 ± 0.256 vs. 0.564 ± 0.19 ms/mmHg, P <0.05). Baroreflex sensitivity returned to prebupivacaine levels by 15 min. Bupivacaine (2 mg/kg), in the presence of atenolol, depressed baroreflex sensitivity (phenylephrine, 0.633 ± 0.204 vs. 0.277 ± 0.282; nitroprusside, 0.653 ± 0.142 vs. 0.320 ± 0.299 ms/mmHg, P <0.05). In contrast, bupivacaine did not alter baroreflex sensitivity in the presence of methyl atropine. Conclusions: Bupivacaine, in clinically relevant concentrations, inhibits baroreflex control of heart rate in conscious rats. This inhibition appears to involve primarily vagal components of the baroreflex-heart rate pathways.

Original languageEnglish (US)
Pages (from-to)197-207
Number of pages11
JournalAnesthesiology
Volume92
Issue number1
StatePublished - Jan 2000

Fingerprint

Baroreflex
Bupivacaine
Heart Rate
Nitroprusside
Phenylephrine
Reflex
Atenolol
Bradycardia
Tachycardia
Blood Pressure
Muscarinic Antagonists
Adrenergic Antagonists
Intravenous Administration
Arterial Pressure
Injections

Keywords

  • Autonomic nervous system
  • Baroreceptors
  • Hypertension
  • Local anesthetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Chang, K. S. K., Morrow, D. R., Kuzume, K., & Andresen, M. (2000). Bupivacaine inhibits baroreflex control of heart rate in conscious rats. Anesthesiology, 92(1), 197-207.

Bupivacaine inhibits baroreflex control of heart rate in conscious rats. / Chang, Kyoung S K; Morrow, Don R.; Kuzume, Kazuyo; Andresen, Michael.

In: Anesthesiology, Vol. 92, No. 1, 01.2000, p. 197-207.

Research output: Contribution to journalArticle

Chang, KSK, Morrow, DR, Kuzume, K & Andresen, M 2000, 'Bupivacaine inhibits baroreflex control of heart rate in conscious rats', Anesthesiology, vol. 92, no. 1, pp. 197-207.
Chang, Kyoung S K ; Morrow, Don R. ; Kuzume, Kazuyo ; Andresen, Michael. / Bupivacaine inhibits baroreflex control of heart rate in conscious rats. In: Anesthesiology. 2000 ; Vol. 92, No. 1. pp. 197-207.
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