Building Blocks for Engineering the Small Intestine

Nicholas R. Smith, Eric Anderson, Paige Davies, Melissa Wong

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bowel transplantation represents the current standard of care for patients suffering from severe intestinal disorders such as short bowel syndrome. Despite improvements in surgical procedures, there remains an approximate 50% 5-year survival rate for intestinal transplant patients [55]. Currently, the primary barriers to successful organ transplantation are the lack of transplantable tissue, the potential for transplant rejection, and the requirement of lifelong immunosuppression [35]. These challenges highlight the need to fully explore the developing field of intestinal epithelial stem cell biology and their ability for ex vivo expansion of tissue in order to reach the ultimate goal of engineering personalized transplantable intestine from patient-derived cells.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages551-559
Number of pages9
ISBN (Print)9780123985231
DOIs
StatePublished - 2014

Fingerprint

Transplants
Small Intestine
Cytology
Tissue
Transplantation (surgical)
Stem cells
Tissue Expansion
Short Bowel Syndrome
Graft Rejection
Organ Transplantation
Standard of Care
Immunosuppression
Intestines
Cell Biology
Stem Cells
Survival Rate
Transplantation
Epithelial Cells

Keywords

  • Bowel
  • Epithelial
  • Immunosuppression
  • Intestinal
  • Patients
  • Short bowel syndrome
  • Stem cell
  • Transplantable tissue
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Smith, N. R., Anderson, E., Davies, P., & Wong, M. (2014). Building Blocks for Engineering the Small Intestine. In Regenerative Medicine Applications in Organ Transplantation (pp. 551-559). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00037-9

Building Blocks for Engineering the Small Intestine. / Smith, Nicholas R.; Anderson, Eric; Davies, Paige; Wong, Melissa.

Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. p. 551-559.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smith, NR, Anderson, E, Davies, P & Wong, M 2014, Building Blocks for Engineering the Small Intestine. in Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., pp. 551-559. https://doi.org/10.1016/B978-0-12-398523-1.00037-9
Smith NR, Anderson E, Davies P, Wong M. Building Blocks for Engineering the Small Intestine. In Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc. 2014. p. 551-559 https://doi.org/10.1016/B978-0-12-398523-1.00037-9
Smith, Nicholas R. ; Anderson, Eric ; Davies, Paige ; Wong, Melissa. / Building Blocks for Engineering the Small Intestine. Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. pp. 551-559
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