BST-2/tetherin

Viral tether, viral sensor or both?

Jean Gustin, Janet Douglas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the fields of virology and innate immunity, BST-2/tetherin is well known for its ability to block the egress of enveloped viruses from infected cells. This appears to be accomplished by 'tethering' virions to the cell surface, thereby limiting virion release. In the past year, several groups have discovered that BST-2/tetherin can activate NF-κB, a transcriptional activator that leads to the rapid expression of both proinflammatory cytokines and proteins involved in cell survival. While this new BST-2 function has been interpreted as a possible viral-sensing mechanism, there may also be broader implications for HIV gene regulation. This article reviews the evidence for BST-2-dependent NF-κB activation, and explores the significance of these exciting new results.

Original languageEnglish (US)
Pages (from-to)1053-1060
Number of pages8
JournalFuture Virology
Volume8
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Virion
Virus Release
Virology
Innate Immunity
Cell Survival
HIV
Cytokines
Genes
Proteins

Keywords

  • BST-2
  • CD317
  • egress
  • HIV
  • NF-κB
  • SIV
  • tetherin
  • viral sensor

ASJC Scopus subject areas

  • Virology

Cite this

BST-2/tetherin : Viral tether, viral sensor or both? / Gustin, Jean; Douglas, Janet.

In: Future Virology, Vol. 8, No. 11, 11.2013, p. 1053-1060.

Research output: Contribution to journalArticle

Gustin, Jean ; Douglas, Janet. / BST-2/tetherin : Viral tether, viral sensor or both?. In: Future Virology. 2013 ; Vol. 8, No. 11. pp. 1053-1060.
@article{93b72b58c03541289e7ddbe81e80e8ac,
title = "BST-2/tetherin: Viral tether, viral sensor or both?",
abstract = "In the fields of virology and innate immunity, BST-2/tetherin is well known for its ability to block the egress of enveloped viruses from infected cells. This appears to be accomplished by 'tethering' virions to the cell surface, thereby limiting virion release. In the past year, several groups have discovered that BST-2/tetherin can activate NF-κB, a transcriptional activator that leads to the rapid expression of both proinflammatory cytokines and proteins involved in cell survival. While this new BST-2 function has been interpreted as a possible viral-sensing mechanism, there may also be broader implications for HIV gene regulation. This article reviews the evidence for BST-2-dependent NF-κB activation, and explores the significance of these exciting new results.",
keywords = "BST-2, CD317, egress, HIV, NF-κB, SIV, tetherin, viral sensor",
author = "Jean Gustin and Janet Douglas",
year = "2013",
month = "11",
doi = "10.2217/fvl.13.96",
language = "English (US)",
volume = "8",
pages = "1053--1060",
journal = "Future Virology",
issn = "1746-0794",
publisher = "Future Medicine Ltd.",
number = "11",

}

TY - JOUR

T1 - BST-2/tetherin

T2 - Viral tether, viral sensor or both?

AU - Gustin, Jean

AU - Douglas, Janet

PY - 2013/11

Y1 - 2013/11

N2 - In the fields of virology and innate immunity, BST-2/tetherin is well known for its ability to block the egress of enveloped viruses from infected cells. This appears to be accomplished by 'tethering' virions to the cell surface, thereby limiting virion release. In the past year, several groups have discovered that BST-2/tetherin can activate NF-κB, a transcriptional activator that leads to the rapid expression of both proinflammatory cytokines and proteins involved in cell survival. While this new BST-2 function has been interpreted as a possible viral-sensing mechanism, there may also be broader implications for HIV gene regulation. This article reviews the evidence for BST-2-dependent NF-κB activation, and explores the significance of these exciting new results.

AB - In the fields of virology and innate immunity, BST-2/tetherin is well known for its ability to block the egress of enveloped viruses from infected cells. This appears to be accomplished by 'tethering' virions to the cell surface, thereby limiting virion release. In the past year, several groups have discovered that BST-2/tetherin can activate NF-κB, a transcriptional activator that leads to the rapid expression of both proinflammatory cytokines and proteins involved in cell survival. While this new BST-2 function has been interpreted as a possible viral-sensing mechanism, there may also be broader implications for HIV gene regulation. This article reviews the evidence for BST-2-dependent NF-κB activation, and explores the significance of these exciting new results.

KW - BST-2

KW - CD317

KW - egress

KW - HIV

KW - NF-κB

KW - SIV

KW - tetherin

KW - viral sensor

UR - http://www.scopus.com/inward/record.url?scp=84886692752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886692752&partnerID=8YFLogxK

U2 - 10.2217/fvl.13.96

DO - 10.2217/fvl.13.96

M3 - Article

VL - 8

SP - 1053

EP - 1060

JO - Future Virology

JF - Future Virology

SN - 1746-0794

IS - 11

ER -