Bringing Order to the Glutamate Chaos in Schizophrenia

Research output: Contribution to journalReview articlepeer-review

350 Scopus citations


Recent genetic linkage studies complement the existing evidence that implicates abnormalities in NMDA receptor-mediated neurotransmission in the pathophysiology of schizophrenia. At the same time, advances in our understanding of the complex mechanisms that modulate the function of NMDA receptors suggest several novel sites for pharmacological manipulation of these receptors. This presents exciting opportunities for rational rather than serendipitous discovery of therapeutics for schizophrenia.

Original languageEnglish (US)
Pages (from-to)881-884
Number of pages4
Issue number5
StatePublished - Dec 4 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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