Bridging the gap between the human and macaque connectome

A quantitative comparison of global interspecies structure-function relationships and network topology

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Resting state functional connectivity MRI (rs-fcMRI) may provide a powerful and noninvasive "bridge" for comparing brain function between patients and experimental animal models; however, the relationship between human and macaque rs-fcMRI remains poorly understood. Here, using a novel surface deformation process for species comparisons in the same anatomical space (Van Essen, 2004, 2005), we found high correspondence, but also unique hub topology, between human and macaque functional connectomes. The global functional connectivity match between species was moderate to strong (r 0.41) and increased when considering the top 15% strongest connections (r 0.54). Analysis of the match between functional connectivity and the underlying anatomical connectivity, derived from a previous retrograde tracer study done in macaques (Markov et al., 2012), showed impressive structure-function correspondence in both the macaque and human. When examining the strongest structural connections, we found a 70-80% match between structural and functional connectivity matrices in both species. Finally, we compare species on two widely used metrics for studying hub topology: degree and betweenness centrality. The data showed topological agreement across the species, with nodes of the posterior cingulate showing high degree and betweenness centrality. In contrast, nodes in medial frontal and parietal cortices were identified as having high degree and betweenness in the human as opposed to the macaque. Our results provide: (1) a thorough examination and validation for a surface-based interspecies deformation process, (2) a strong theoretical foundation for making interspecies comparisons of rs-fcMRI, and (3) a unique look at topological distinctions between the species.

Original languageEnglish (US)
Pages (from-to)5552-5563
Number of pages12
JournalJournal of Neuroscience
Volume34
Issue number16
DOIs
StatePublished - 2014

Fingerprint

Connectome
Macaca
Magnetic Resonance Imaging
Parietal Lobe
Gyrus Cinguli
Frontal Lobe
Animal Models
Brain

Keywords

  • Graph theory
  • Macaque functional connectivity
  • Network topology
  • Resting state functional connectivity MRI
  • Structure function relationships

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{d789f0e445ae445fb00e6225dfd46d4f,
title = "Bridging the gap between the human and macaque connectome: A quantitative comparison of global interspecies structure-function relationships and network topology",
abstract = "Resting state functional connectivity MRI (rs-fcMRI) may provide a powerful and noninvasive {"}bridge{"} for comparing brain function between patients and experimental animal models; however, the relationship between human and macaque rs-fcMRI remains poorly understood. Here, using a novel surface deformation process for species comparisons in the same anatomical space (Van Essen, 2004, 2005), we found high correspondence, but also unique hub topology, between human and macaque functional connectomes. The global functional connectivity match between species was moderate to strong (r 0.41) and increased when considering the top 15{\%} strongest connections (r 0.54). Analysis of the match between functional connectivity and the underlying anatomical connectivity, derived from a previous retrograde tracer study done in macaques (Markov et al., 2012), showed impressive structure-function correspondence in both the macaque and human. When examining the strongest structural connections, we found a 70-80{\%} match between structural and functional connectivity matrices in both species. Finally, we compare species on two widely used metrics for studying hub topology: degree and betweenness centrality. The data showed topological agreement across the species, with nodes of the posterior cingulate showing high degree and betweenness centrality. In contrast, nodes in medial frontal and parietal cortices were identified as having high degree and betweenness in the human as opposed to the macaque. Our results provide: (1) a thorough examination and validation for a surface-based interspecies deformation process, (2) a strong theoretical foundation for making interspecies comparisons of rs-fcMRI, and (3) a unique look at topological distinctions between the species.",
keywords = "Graph theory, Macaque functional connectivity, Network topology, Resting state functional connectivity MRI, Structure function relationships",
author = "{Miranda Dominguez}, Oscar and Mills, {Brian D.} and David Grayson and Andrew Woodall and Grant, {Kathleen (Kathy)} and Kroenke, {Christopher (Chris)} and Damien Fair",
year = "2014",
doi = "10.1523/JNEUROSCI.4229-13.2014",
language = "English (US)",
volume = "34",
pages = "5552--5563",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "16",

}

TY - JOUR

T1 - Bridging the gap between the human and macaque connectome

T2 - A quantitative comparison of global interspecies structure-function relationships and network topology

AU - Miranda Dominguez, Oscar

AU - Mills, Brian D.

AU - Grayson, David

AU - Woodall, Andrew

AU - Grant, Kathleen (Kathy)

AU - Kroenke, Christopher (Chris)

AU - Fair, Damien

PY - 2014

Y1 - 2014

N2 - Resting state functional connectivity MRI (rs-fcMRI) may provide a powerful and noninvasive "bridge" for comparing brain function between patients and experimental animal models; however, the relationship between human and macaque rs-fcMRI remains poorly understood. Here, using a novel surface deformation process for species comparisons in the same anatomical space (Van Essen, 2004, 2005), we found high correspondence, but also unique hub topology, between human and macaque functional connectomes. The global functional connectivity match between species was moderate to strong (r 0.41) and increased when considering the top 15% strongest connections (r 0.54). Analysis of the match between functional connectivity and the underlying anatomical connectivity, derived from a previous retrograde tracer study done in macaques (Markov et al., 2012), showed impressive structure-function correspondence in both the macaque and human. When examining the strongest structural connections, we found a 70-80% match between structural and functional connectivity matrices in both species. Finally, we compare species on two widely used metrics for studying hub topology: degree and betweenness centrality. The data showed topological agreement across the species, with nodes of the posterior cingulate showing high degree and betweenness centrality. In contrast, nodes in medial frontal and parietal cortices were identified as having high degree and betweenness in the human as opposed to the macaque. Our results provide: (1) a thorough examination and validation for a surface-based interspecies deformation process, (2) a strong theoretical foundation for making interspecies comparisons of rs-fcMRI, and (3) a unique look at topological distinctions between the species.

AB - Resting state functional connectivity MRI (rs-fcMRI) may provide a powerful and noninvasive "bridge" for comparing brain function between patients and experimental animal models; however, the relationship between human and macaque rs-fcMRI remains poorly understood. Here, using a novel surface deformation process for species comparisons in the same anatomical space (Van Essen, 2004, 2005), we found high correspondence, but also unique hub topology, between human and macaque functional connectomes. The global functional connectivity match between species was moderate to strong (r 0.41) and increased when considering the top 15% strongest connections (r 0.54). Analysis of the match between functional connectivity and the underlying anatomical connectivity, derived from a previous retrograde tracer study done in macaques (Markov et al., 2012), showed impressive structure-function correspondence in both the macaque and human. When examining the strongest structural connections, we found a 70-80% match between structural and functional connectivity matrices in both species. Finally, we compare species on two widely used metrics for studying hub topology: degree and betweenness centrality. The data showed topological agreement across the species, with nodes of the posterior cingulate showing high degree and betweenness centrality. In contrast, nodes in medial frontal and parietal cortices were identified as having high degree and betweenness in the human as opposed to the macaque. Our results provide: (1) a thorough examination and validation for a surface-based interspecies deformation process, (2) a strong theoretical foundation for making interspecies comparisons of rs-fcMRI, and (3) a unique look at topological distinctions between the species.

KW - Graph theory

KW - Macaque functional connectivity

KW - Network topology

KW - Resting state functional connectivity MRI

KW - Structure function relationships

UR - http://www.scopus.com/inward/record.url?scp=84899486517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899486517&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.4229-13.2014

DO - 10.1523/JNEUROSCI.4229-13.2014

M3 - Article

VL - 34

SP - 5552

EP - 5563

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 16

ER -