To the Editor: The role in humans of pulmonary afferent neuronal pathways in setting the level and pattern of ventilation during exercise has been long debated. Sciurba et al. (Nov. 3 issue)1 recently found that inspiratory ventilation was depressed at peak exercise in a group of patients whose pulmonary innervation had been interrupted at the time of heart–lung transplantation, when compared with patients who had undergone heart transplantation only. The inspiratory ventilation is directly dependent on carbon dioxide production and the ratio of dead space to tidal volume (Vd/Vt), whereas it is indirectly related to partial pressure of arterial carbon….
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