Breast fine-needle aspirates with scant cellularity are clinically useful

John Vetto, Rodney Pommier, Richard L. Shih, Jess Campagna, Debra Robbins, Waldemar A. Schmidt, Alan Morgan

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Introduction: Fine-needle aspirates (FNAs) with scant cellularity are considered inadequate by current cytopathology standards. We hypothesized that such aspirates are clinically useful. Methods: A 10-year database of palpable breast lumps evaluated by FNA-based triple test (TT; FNA, breast imaging studies, and clinical breast examination) and triple test scores (TTSs; 3-9) was examined to identify FNAs with scant cellularity but without evidence of malignancy (negative SC-FNAs). These FNAs were correlated with the occurrence of any subsequent cancers (false-negative SC-FNAs) and with TTSs. Results: Among a total of 324 negative SC-FNAs, 9 cancers were subsequently found at sampled sites. Seven were associated with a suspicious or malignant TTS (scores of 5 or greater) and therefore still correctly diagnosed as malignant or suspicious for malignancy. The remaining two cancers were missed by both SC-FNA and TTS (false-negative rate for TTS of 0.6%); both had scores of 4 because of suspicious imaging. Conclusions: Scantly cellular but negative FNAs are useful (can avoid unnecessary invasive breast biopsy) in the evaluation of palpable breast masses, especially when interpreted in the context of the TT and TTS.

    Original languageEnglish (US)
    Pages (from-to)621-626
    Number of pages6
    JournalAmerican Journal of Surgery
    Volume189
    Issue number5 SPEC. ISS.
    DOIs
    StatePublished - May 2005

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    Needles
    Breast
    Neoplasms
    antineoplaston A10
    Databases
    Biopsy

    Keywords

    • False-negative rate
    • Fine-needle aspiration
    • Positive predictive value
    • Scant cellularity
    • Triple test score

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Breast fine-needle aspirates with scant cellularity are clinically useful. / Vetto, John; Pommier, Rodney; Shih, Richard L.; Campagna, Jess; Robbins, Debra; Schmidt, Waldemar A.; Morgan, Alan.

    In: American Journal of Surgery, Vol. 189, No. 5 SPEC. ISS., 05.2005, p. 621-626.

    Research output: Contribution to journalArticle

    Vetto, J, Pommier, R, Shih, RL, Campagna, J, Robbins, D, Schmidt, WA & Morgan, A 2005, 'Breast fine-needle aspirates with scant cellularity are clinically useful', American Journal of Surgery, vol. 189, no. 5 SPEC. ISS., pp. 621-626. https://doi.org/10.1016/j.amjsurg.2005.01.040
    Vetto, John ; Pommier, Rodney ; Shih, Richard L. ; Campagna, Jess ; Robbins, Debra ; Schmidt, Waldemar A. ; Morgan, Alan. / Breast fine-needle aspirates with scant cellularity are clinically useful. In: American Journal of Surgery. 2005 ; Vol. 189, No. 5 SPEC. ISS. pp. 621-626.
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    abstract = "Introduction: Fine-needle aspirates (FNAs) with scant cellularity are considered inadequate by current cytopathology standards. We hypothesized that such aspirates are clinically useful. Methods: A 10-year database of palpable breast lumps evaluated by FNA-based triple test (TT; FNA, breast imaging studies, and clinical breast examination) and triple test scores (TTSs; 3-9) was examined to identify FNAs with scant cellularity but without evidence of malignancy (negative SC-FNAs). These FNAs were correlated with the occurrence of any subsequent cancers (false-negative SC-FNAs) and with TTSs. Results: Among a total of 324 negative SC-FNAs, 9 cancers were subsequently found at sampled sites. Seven were associated with a suspicious or malignant TTS (scores of 5 or greater) and therefore still correctly diagnosed as malignant or suspicious for malignancy. The remaining two cancers were missed by both SC-FNA and TTS (false-negative rate for TTS of 0.6{\%}); both had scores of 4 because of suspicious imaging. Conclusions: Scantly cellular but negative FNAs are useful (can avoid unnecessary invasive breast biopsy) in the evaluation of palpable breast masses, especially when interpreted in the context of the TT and TTS.",
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    AU - Schmidt, Waldemar A.

    AU - Morgan, Alan

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