TY - JOUR
T1 - Breast cancer biobank from a single institutional cohort in an urban setting in india
T2 - Tumor characteristics and survival outcomes
AU - Busheri, Laleh
AU - Dixit, Santosh
AU - Nare, Smeeta
AU - Alhat, Rashmi
AU - Thomas, George
AU - Jagtap, Mangal
AU - Navgire, Ruth
AU - Shinde, Priya
AU - Banale, Rituja
AU - Unde, Rohini
AU - Reddy, Ruhi
AU - Shaikh, Shahin
AU - Konnur, Aishwarya
AU - Namewar, Namrata
AU - Bapat, Ashwini
AU - Patil, Ankita
AU - Johari, Rateeka
AU - Kushwaha, Roli
AU - Kumari, Wimpy
AU - Varghese, Beenu
AU - Deshpande, Pooja
AU - Deshmukh, Chetan
AU - Kelkar, Devaki A.
AU - Shashidhara, L. S.
AU - Koppiker, Chaitanyanand B.
AU - Kulkarni, Madhura
N1 - Publisher Copyright:
© 2021
PY - 2021/1
Y1 - 2021/1
N2 - Background: A breast cancer biobank with retrospectively collected patient data and FFPE tissue samples was established in 2018 at Prashanti Cancer Care Mission, Pune, India. It runs a cancer care clinic with support from a single surgeon's breast cancer practice. The clinical data and tissue sample collection is undertaken with appropriate patient consent following ethical approval and guidelines. Methods: The biobank holds clinical history, diagnostic reports, treatment and follow-up information along with FFPE tumor tissue specimens, adjacent normal and, in few cases, contralateral normal breast tissue. Detailed family history and germline mutational profiles of eligible and consenting patients and their relatives are also deposited in the biobank. Results: Here, we report the first audit of the biobank. A total number of 994 patients with breast disease have deposited consented clinical records in the biobank. The majority of the records (80%, n = 799) are of patients with infiltrating ductal carcinoma (IDC). Of 799 IDC patients, 434 (55%) have deposited tumor tissue in the biobank with consent. In addition, germline mutation profiles of 84 patients and their family members are deposited. Follow-up information is available for 85% of the 434 IDC patients with an average follow-up of 3 years. Conclusion: The biobank has aided the initiation of translational research at our center in collaboration with eminent institutes like IISER Pune and SJRI Bangalore to evaluate profiles of breast cancer in an Indian cohort. The biobank will be a valuable resource to the breast cancer research community, especially to understand South Asian profiles of breast cancer.
AB - Background: A breast cancer biobank with retrospectively collected patient data and FFPE tissue samples was established in 2018 at Prashanti Cancer Care Mission, Pune, India. It runs a cancer care clinic with support from a single surgeon's breast cancer practice. The clinical data and tissue sample collection is undertaken with appropriate patient consent following ethical approval and guidelines. Methods: The biobank holds clinical history, diagnostic reports, treatment and follow-up information along with FFPE tumor tissue specimens, adjacent normal and, in few cases, contralateral normal breast tissue. Detailed family history and germline mutational profiles of eligible and consenting patients and their relatives are also deposited in the biobank. Results: Here, we report the first audit of the biobank. A total number of 994 patients with breast disease have deposited consented clinical records in the biobank. The majority of the records (80%, n = 799) are of patients with infiltrating ductal carcinoma (IDC). Of 799 IDC patients, 434 (55%) have deposited tumor tissue in the biobank with consent. In addition, germline mutation profiles of 84 patients and their family members are deposited. Follow-up information is available for 85% of the 434 IDC patients with an average follow-up of 3 years. Conclusion: The biobank has aided the initiation of translational research at our center in collaboration with eminent institutes like IISER Pune and SJRI Bangalore to evaluate profiles of breast cancer in an Indian cohort. The biobank will be a valuable resource to the breast cancer research community, especially to understand South Asian profiles of breast cancer.
KW - Breast Cancer Biobank
KW - Indian Cohort
KW - Single Surgeon – Cohort
UR - http://www.scopus.com/inward/record.url?scp=85108703835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108703835&partnerID=8YFLogxK
U2 - 10.1016/j.ctarc.2021.100409
DO - 10.1016/j.ctarc.2021.100409
M3 - Article
C2 - 34098400
AN - SCOPUS:85108703835
SN - 2213-0896
VL - 28
JO - Cancer Treatment and Research Communications
JF - Cancer Treatment and Research Communications
M1 - 100409
ER -