Breakdown of stria vascularis blood-labyrinth barrier in C3H/lpr autoimmune disease mice

D. W. Lin, Dennis Trune

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Sensorineural hearing loss related to autoimmune disease is a well- recognized condition, although the exact pathophysiologic mechanisms remain unclear. One current theory postulates immune complex-induced interference with blood-labyrinth barrier integrity in the stria vascularis. The C3H/lpr autoimmune mouse was chosen to study the permeability of capillaries in the stria vascularis because this mouse model has demonstrated abnormalities of the stria vascularis and shifts in the auditory brain stem response threshold durIng active disease. C3H/lpr mice with active disease were compared with younger mice without disease, as well as age-matched C3H/HeJ control mice. The mice were injected with the tracer ferritin and examined by transmission electron microscopy to evaluate the integrity of the capillary tight junctions in the stria vascularis. Four of five mice with active disease were noted to have extensive leakage of ferritin into the perivascular tissues. Neither the young, disease-free autoimmune mice nor the nonautoimmune control mice demonstrated vessel leakage. Thickening of the basement membrane was also noted in the diseased animals. The results imply that active disease leads to a breakdown in the blood-endolymph barrier, which could underlie the hearing loss accompanying autoimmune and other immune diseases.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Volume117
Issue number5
StatePublished - 1997

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Stria Vascularis
Inner Ear
Autoimmune Diseases
Ferritins
Endolymph
Animal Diseases
Brain Stem Auditory Evoked Potentials
Inbred C3H Mouse
Sensorineural Hearing Loss
Tight Junctions
Immune System Diseases
Capillary Permeability
Antigen-Antibody Complex
Transmission Electron Microscopy
Hearing Loss
Basement Membrane

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Breakdown of stria vascularis blood-labyrinth barrier in C3H/lpr autoimmune disease mice. / Lin, D. W.; Trune, Dennis.

In: Otolaryngology - Head and Neck Surgery, Vol. 117, No. 5, 1997, p. 530-534.

Research output: Contribution to journalArticle

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