Brainstem Opioidergic System Is Involved in Early Response to Experimental SAH

Justin Cetas, Robin McFarlane, Kassi Kronfeld, Phoebe Smitasin, Jesse J. Liu, Jeffrey S. Raskin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Subarachnoid hemorrhage (SAH) is a form of stroke with high rates of mortality and permanent disability for patients who survive the initial event. Previous research has focused on delayed cerebral vasospasm of large conduit arteries as the cause of poor long-term outcomes after SAH. New evidence suggests that acute failure to restore cerebral blood flow (CBF) after SAH may be setting the stage for delayed ischemic neurological deficits. Our lab previously demonstrated that the rostral ventromedial medulla (RVM), an autonomic and sensorimotor integration center, is important for maintaining CBF after experimental SAH. In this study, we have demonstrated that ablation of μ-opioid receptor containing cells with dermorphin conjugates in the RVM results in a high mortality rate after experimental SAH and, in survivors, causes a dramatic decrease in CBF. Further, locally blocking the μ-opioid receptor with the antagonist naltrexone attenuated the reduction in CBF secondary to experimental SAH. Saturating μ-opioid receptors with the agonist [d-Ala(2),NMe-Phe(4),Gly-ol(5)]-encephalin (DAMGO) had no effect. Taken together, these results suggest that SAH activates opioidergic signaling in the RVM with a resultant reduction in CBF. Further, cells in the RVM that contain μ-opioid receptors are important for survival after acute SAH. We propose that failure of the RVM μ-opioid receptor cells to initiate the compensatory CBF response sets the stage for acute and delayed ischemic injury following SAH.

Original languageEnglish (US)
Pages (from-to)140-147
Number of pages8
JournalTranslational Stroke Research
Volume6
Issue number2
DOIs
StatePublished - 2015

Fingerprint

Cerebrovascular Circulation
Subarachnoid Hemorrhage
Brain Stem
Opioid Receptors
glycyl-glycyl-glycyl-glycine
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Intracranial Vasospasm
Naltrexone
Narcotic Antagonists
Mortality
Survivors
Arteries
Stroke
Survival
Wounds and Injuries

Keywords

  • Brainstem
  • Cerebral blood flow
  • Modulation
  • Rostral ventromedial medulla
  • Stroke
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Brainstem Opioidergic System Is Involved in Early Response to Experimental SAH. / Cetas, Justin; McFarlane, Robin; Kronfeld, Kassi; Smitasin, Phoebe; Liu, Jesse J.; Raskin, Jeffrey S.

In: Translational Stroke Research, Vol. 6, No. 2, 2015, p. 140-147.

Research output: Contribution to journalArticle

Cetas, Justin ; McFarlane, Robin ; Kronfeld, Kassi ; Smitasin, Phoebe ; Liu, Jesse J. ; Raskin, Jeffrey S. / Brainstem Opioidergic System Is Involved in Early Response to Experimental SAH. In: Translational Stroke Research. 2015 ; Vol. 6, No. 2. pp. 140-147.
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