Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

Karoly Gulya, Kathleen A. Grant, Peter Valverius, Paula L. Hoffman, Boris Tabakoff

    Research output: Contribution to journalArticlepeer-review

    250 Scopus citations

    Abstract

    Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.

    Original languageEnglish (US)
    Pages (from-to)130-134
    Number of pages5
    JournalBrain research
    Volume547
    Issue number1
    DOIs
    StatePublished - Apr 26 1991

    Keywords

    • Ethanol physical dependence
    • Ethanol withdrawal seizure
    • Hippocampus
    • MK-801 autoradiography
    • MK-801 binding
    • NMDA receptor

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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