Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

Karoly Gulya, Kathleen (Kathy) Grant, Peter Valverius, Paula L. Hoffman, Boris Tabakoff

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalBrain Research
Volume547
Issue number1
DOIs
StatePublished - Apr 26 1991
Externally publishedYes

Fingerprint

N-Methyl-D-Aspartate Receptors
Dizocilpine Maleate
Ethanol
Brain
Hippocampus
Seizures
Eating
Autoradiography
Thalamus
Cerebral Cortex
Binding Sites
Membranes

Keywords

  • Ethanol physical dependence
  • Ethanol withdrawal seizure
  • Hippocampus
  • MK-801 autoradiography
  • MK-801 binding
  • NMDA receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. / Gulya, Karoly; Grant, Kathleen (Kathy); Valverius, Peter; Hoffman, Paula L.; Tabakoff, Boris.

In: Brain Research, Vol. 547, No. 1, 26.04.1991, p. 129-134.

Research output: Contribution to journalArticle

Gulya, Karoly ; Grant, Kathleen (Kathy) ; Valverius, Peter ; Hoffman, Paula L. ; Tabakoff, Boris. / Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. In: Brain Research. 1991 ; Vol. 547, No. 1. pp. 129-134.
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