Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

Karoly Gulya; Kathleen A. Grant; Peter Valverius; Paula L. Hoffman; Boris Tabakoff

doi:10.1016/0006-8993(91)90583-H

Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

Karoly Gulya, Kathleen A. Grant, Peter Valverius, Paula L. Hoffman, Boris Tabakoff

Research output: Contribution to journal › Article › peer-review

258 Scopus citations

Abstract

Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.

Original language	English (US)
Pages (from-to)	130-134
Number of pages	5
Journal	Brain research
Volume	547
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)90583-H
State	Published - Apr 26 1991
Externally published	Yes

Keywords

Ethanol physical dependence
Ethanol withdrawal seizure
Hippocampus
MK-801 autoradiography
MK-801 binding
NMDA receptor

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)90583-H

Cite this

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title = "Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal",

abstract = "Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.",

keywords = "Ethanol physical dependence, Ethanol withdrawal seizure, Hippocampus, MK-801 autoradiography, MK-801 binding, NMDA receptor",

author = "Karoly Gulya and Grant, {Kathleen A.} and Peter Valverius and Hoffman, {Paula L.} and Boris Tabakoff",

note = "Funding Information: Acknowledgement. This work was supported in part by the Banbury Foundation.",

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AU - Gulya, Karoly

AU - Grant, Kathleen A.

AU - Valverius, Peter

AU - Hoffman, Paula L.

AU - Tabakoff, Boris

N1 - Funding Information: Acknowledgement. This work was supported in part by the Banbury Foundation.

PY - 1991/4/26

Y1 - 1991/4/26

N2 - Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.

AB - Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.

KW - Ethanol physical dependence

KW - Ethanol withdrawal seizure

KW - Hippocampus

KW - MK-801 autoradiography

KW - MK-801 binding

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Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

Abstract

Keywords

ASJC Scopus subject areas

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