Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

Karoly Gulya, Kathleen A. Grant, Peter Valverius, Paula L. Hoffman, Boris Tabakoff

Research output: Contribution to journalArticlepeer-review

250 Scopus citations

Abstract

Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cortex, striatum and thalamus, as well as in hippocampus. The persistence of changes in MK-801 binding paralleled the time-course for ethanol withdrawal seizure susceptibility. These results support the hypothesis that an increase in the number of NMDA receptor/channel complexes in hippocampus, and possibly other brain regions, plays a role in the generation or expression of ethanol withdrawal seizures.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalBrain research
Volume547
Issue number1
DOIs
StatePublished - Apr 26 1991
Externally publishedYes

Keywords

  • Ethanol physical dependence
  • Ethanol withdrawal seizure
  • Hippocampus
  • MK-801 autoradiography
  • MK-801 binding
  • NMDA receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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