Brain-pineal nervous connections in the rat

An ultrastructure study following habenular lesion

Oline Ronnekleiv, M. Møller

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The neural connections of the pineal gland with the central nervous system (CNS) were studied in rats by stereotaxic lesioning followed by electron microscopic determination of nerve terminal degeneration. Electrolytic lesions were placed in the right medial habenular nucleus and after 3-14 days survival, the animals were prepared for electron microscopy. Control animals contained nerve terminals with 40-60 nm dense core vesicles located in the perivascular space of the pineal and in the intraparenchymal area. In the lesioned animals many electron-lucent degenerating nerve terminals could be observed intermingled with normal nerve terminals in the perivascular spaces. These degenerating terminals were often swollen and contained only a few vesicles, which could be seen clustered together and displaced to one side of the terminal. Both normal and degenerating nerve terminals were also observed in the parenchyma between the pinealocytes. The present findings indicate that nerve fibers from the habenular area actually terminate in the rat pineal gland.

Original languageEnglish (US)
Pages (from-to)551-562
Number of pages12
JournalExperimental Brain Research
Volume37
Issue number3
DOIs
StatePublished - Nov 1979
Externally publishedYes

Fingerprint

Pineal Gland
Brain
Electrons
Habenula
Nerve Degeneration
Secretory Vesicles
Nerve Fibers
Electron Microscopy
Central Nervous System

Keywords

  • Habenula
  • Pineal
  • Stereotaxic lesion
  • Terminal degeneration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brain-pineal nervous connections in the rat : An ultrastructure study following habenular lesion. / Ronnekleiv, Oline; Møller, M.

In: Experimental Brain Research, Vol. 37, No. 3, 11.1979, p. 551-562.

Research output: Contribution to journalArticle

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