Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment

Wei Huang, Zygmunt Galdzicki, Peter Van Gelderen, Andrea Balbo, Elsbeth G. Chikhale, Mark B. Schapiro, Stanley I. Rapoport

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change = 18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with 1H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change - 15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalNeuroReport
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Down syndrome
  • Lithium
  • Magnetic resonance spectroscopy
  • Myo-inositol
  • N- acetylaspartate
  • Ts65Dn

ASJC Scopus subject areas

  • Neuroscience(all)

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    Huang, W., Galdzicki, Z., Van Gelderen, P., Balbo, A., Chikhale, E. G., Schapiro, M. B., & Rapoport, S. I. (2000). Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. NeuroReport, 11(3), 445-448. https://doi.org/10.1097/00001756-200002280-00004