The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change = 18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with 1H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change - 15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. (C) 2000 Lippincott Williams and Wilkins.
- Down syndrome
- Magnetic resonance spectroscopy
- N- acetylaspartate
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