Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment

Wei Huang; Zygmunt Galdzicki; Peter Van Gelderen; Andrea Balbo; Elsbeth G. Chikhale; Mark B. Schapiro; Stanley I. Rapoport

doi:10.1097/00001756-200002280-00004

Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment

Wei Huang, Zygmunt Galdzicki, Peter Van Gelderen, Andrea Balbo, Elsbeth G. Chikhale, Mark B. Schapiro, Stanley I. Rapoport

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo ¹H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change = 18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with ¹H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change - 15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. (C) 2000 Lippincott Williams and Wilkins.

Original language	English (US)
Pages (from-to)	445-448
Number of pages	4
Journal	NeuroReport
Volume	11
Issue number	3
DOIs	https://doi.org/10.1097/00001756-200002280-00004
State	Published - 2000
Externally published	Yes

Keywords

Down syndrome
Lithium
Magnetic resonance spectroscopy
Myo-inositol
N- acetylaspartate
Ts65Dn

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-200002280-00004

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title = "Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment",

abstract = "The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change = 18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with 1H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change - 15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. (C) 2000 Lippincott Williams and Wilkins.",

keywords = "Down syndrome, Lithium, Magnetic resonance spectroscopy, Myo-inositol, N- acetylaspartate, Ts65Dn",

author = "Wei Huang and Zygmunt Galdzicki and {Van Gelderen}, Peter and Andrea Balbo and Chikhale, {Elsbeth G.} and Schapiro, {Mark B.} and Rapoport, {Stanley I.}",

year = "2000",

doi = "10.1097/00001756-200002280-00004",

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AU - Huang, Wei

AU - Galdzicki, Zygmunt

AU - Van Gelderen, Peter

AU - Balbo, Andrea

AU - Chikhale, Elsbeth G.

AU - Schapiro, Mark B.

AU - Rapoport, Stanley I.

PY - 2000

Y1 - 2000

N2 - The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change = 18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with 1H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change - 15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. (C) 2000 Lippincott Williams and Wilkins.

AB - The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change = 18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with 1H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change - 15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. (C) 2000 Lippincott Williams and Wilkins.

KW - Down syndrome

KW - Lithium

KW - Magnetic resonance spectroscopy

KW - Myo-inositol

KW - N- acetylaspartate

KW - Ts65Dn

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Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment

Abstract

Keywords

ASJC Scopus subject areas

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