Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Ines Mahjoub, Mohamed Ali Mahjoub, Islem Rekik, Michael Weiner, Paul Aisen, Ronald Petersen, Cliford Jack, William Jagust, John Trojanowki, Arthur Toga, Laurel Beckett, Robert Green, Andrew Saykin, John Morris, Leslie Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter & 221 others Sara Dolen, Lon Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith Heidebrink, Joanne Lord, Sara Mason, Colleen Albers, David Knopman, Kris Johnson, Rachelle Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence Honig, Karen Bell, Beau Ances, Maria Carroll, Mary Creech, Erin Franklin, Mark Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Grifth, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Efe Mitsis, Raj Shah, Leyla Detoledo-Morrell, Ranjan Duara, Daniel Varon, Maria Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James Galvin, Brittany Cerbone, Christina Michel, Dana Pogorelec, Henry Rusinek, Mony De Leon, Lidia Glodzik, Susan De Santi, P. Doraiswamy, Jefrey Petrella, Salvador Borges-Neto, Terence Wong, Edward Coleman, Charles Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton Porsteinsson, Bonnie Goldstein, Kim Martin, Kelly Makino, M. Ismail, Connie Brand, Ruth Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan Levey, James Lah, Janet Cellar, Jefrey Burns, Russell Swerdlow, William Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po Lu, George Bartzokis, Neill Graf-Radford, Francine Parftt, Tracy Kendall, Heather Johnson, Martin Farlow, Ann Marie Hake, Brandy Matthews, Jared Brosch, Scott Herring, Cynthia Hunt, Christopher Dyck, Richard Carson, Martha MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa Sperling, Keith Johnson, Gad Marshall, Jerome Yesavage, Joy Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan Sabbagh, Christine Belden, Sandra Jacobson, Sherye Sirrel, Neil Kowall, Ronald Killiany, Andrew Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles Decarli, Owen Carmichael, Smita Kittur, Michael Borrie, T. Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia Carlsson, Steven Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas Scharre, Maria Kataki, Anahita Adeli, Earl Zimmerman, Dzintra Celmins, Alice Brown, Godfrey Pearlson, Karen Blank, Karen Anderson, Laura Flashman, Marc Seltzer, Mary Hynes, Robert Santulli, Kaycee Sink, Leslie Gordineer, Jef Williamson, Pradeep Garg, Franklin Watkins, Brian Ott, Henry Querfurth, Geofrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard Rosen, Bruce Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus.

Original languageEnglish (US)
Article number4103
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Biomarkers
Brain
Patient treatment
Electric network analysis
Magnetic resonance imaging

ASJC Scopus subject areas

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Cite this

Mahjoub, I., Mahjoub, M. A., Rekik, I., Weiner, M., Aisen, P., Petersen, R., ... Fargher, K. (2018). Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states. Scientific Reports, 8(1), [4103]. https://doi.org/10.1038/s41598-018-21568-7

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states. / Mahjoub, Ines; Mahjoub, Mohamed Ali; Rekik, Islem; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Cliford; Jagust, William; Trojanowki, John; Toga, Arthur; Beckett, Laurel; Green, Robert; Saykin, Andrew; Morris, John; Shaw, Leslie; Kaye, Jeffrey; Quinn, Joseph; Silbert, Lisa; Lind, Betty; Carter, Raina; Dolen, Sara; Schneider, Lon; Pawluczyk, Sonia; Beccera, Mauricio; Teodoro, Liberty; Spann, Bryan; Brewer, James; Vanderswag, Helen; Fleisher, Adam; Heidebrink, Judith; Lord, Joanne; Mason, Sara; Albers, Colleen; Knopman, David; Johnson, Kris; Doody, Rachelle; Villanueva-Meyer, Javier; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; Honig, Lawrence; Bell, Karen; Ances, Beau; Carroll, Maria; Creech, Mary; Franklin, Erin; Mintun, Mark; Schneider, Stacy; Oliver, Angela; Marson, Daniel; Grifth, Randall; Clark, David; Geldmacher, David; Brockington, John; Roberson, Erik; Natelson Love, Marissa; Grossman, Hillel; Mitsis, Efe; Shah, Raj; Detoledo-Morrell, Leyla; Duara, Ranjan; Varon, Daniel; Greig, Maria; Roberts, Peggy; Albert, Marilyn; Onyike, Chiadi; D'Agostino, Daniel; Kielb, Stephanie; Galvin, James; Cerbone, Brittany; Michel, Christina; Pogorelec, Dana; Rusinek, Henry; De Leon, Mony; Glodzik, Lidia; De Santi, Susan; Doraiswamy, P.; Petrella, Jefrey; Borges-Neto, Salvador; Wong, Terence; Coleman, Edward; Smith, Charles; Jicha, Greg; Hardy, Peter; Sinha, Partha; Oates, Elizabeth; Conrad, Gary; Porsteinsson, Anton; Goldstein, Bonnie; Martin, Kim; Makino, Kelly; Ismail, M.; Brand, Connie; Mulnard, Ruth; Thai, Gaby; Mc-Adams-Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Levey, Allan; Lah, James; Cellar, Janet; Burns, Jefrey; Swerdlow, Russell; Brooks, William; Apostolova, Liana; Tingus, Kathleen; Woo, Ellen; Silverman, Daniel; Lu, Po; Bartzokis, George; Graf-Radford, Neill; Parftt, Francine; Kendall, Tracy; Johnson, Heather; Farlow, Martin; Hake, Ann Marie; Matthews, Brandy; Brosch, Jared; Herring, Scott; Hunt, Cynthia; Dyck, Christopher; Carson, Richard; MacAvoy, Martha; Varma, Pradeep; Chertkow, Howard; Bergman, Howard; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Robin Hsiung, Ging Yuek; Feldman, Howard; Mudge, Benita; Assaly, Michele; Finger, Elizabeth; Pasternack, Stephen; Rachisky, Irina; Trost, Dick; Kertesz, Andrew; Bernick, Charles; Munic, Donna; Mesulam, Marek Marsel; Lipowski, Kristine; Weintraub, Sandra; Bonakdarpour, Borna; Kerwin, Diana; Wu, Chuang Kuo; Johnson, Nancy; Sadowsky, Carl; Villena, Teresa; Turner, Raymond Scott; Johnson, Kathleen; Reynolds, Brigid; Sperling, Reisa; Johnson, Keith; Marshall, Gad; Yesavage, Jerome; Taylor, Joy; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Sabbagh, Marwan; Belden, Christine; Jacobson, Sandra; Sirrel, Sherye; Kowall, Neil; Killiany, Ronald; Budson, Andrew; Norbash, Alexander; Johnson, Patricia Lynn; Obisesan, Thomas; Wolday, Saba; Allard, Joanne; Lerner, Alan; Ogrocki, Paula; Tatsuoka, Curtis; Fatica, Parianne; Fletcher, Evan; Maillard, Pauline; Olichney, John; Decarli, Charles; Carmichael, Owen; Kittur, Smita; Borrie, Michael; Lee, T. Y.; Bartha, Rob; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia; Potkin, Steven; Preda, Adrian; Nguyen, Dana; Tariot, Pierre; Burke, Anna; Trncic, Nadira; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Scharre, Douglas; Kataki, Maria; Adeli, Anahita; Zimmerman, Earl; Celmins, Dzintra; Brown, Alice; Pearlson, Godfrey; Blank, Karen; Anderson, Karen; Flashman, Laura; Seltzer, Marc; Hynes, Mary; Santulli, Robert; Sink, Kaycee; Gordineer, Leslie; Williamson, Jef; Garg, Pradeep; Watkins, Franklin; Ott, Brian; Querfurth, Henry; Tremont, Geofrey; Salloway, Stephen; Malloy, Paul; Correia, Stephen; Rosen, Howard; Miller, Bruce; Perry, David; Mintzer, Jacobo; Spicer, Kenneth; Bachman, David; Pomara, Nunzio; Hernando, Raymundo; Sarrael, Antero; Relkin, Norman; Chaing, Gloria; Lin, Michael; Ravdin, Lisa; Smith, Amanda; Raj, Balebail Ashok; Fargher, Kristin.

In: Scientific Reports, Vol. 8, No. 1, 4103, 01.12.2018.

Research output: Contribution to journalArticle

Mahjoub, I, Mahjoub, MA, Rekik, I, Weiner, M, Aisen, P, Petersen, R, Jack, C, Jagust, W, Trojanowki, J, Toga, A, Beckett, L, Green, R, Saykin, A, Morris, J, Shaw, L, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, L, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, B, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, J, Lord, J, Mason, S, Albers, C, Knopman, D, Johnson, K, Doody, R, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Bell, K, Ances, B, Carroll, M, Creech, M, Franklin, E, Mintun, M, Schneider, S, Oliver, A, Marson, D, Grifth, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Natelson Love, M, Grossman, H, Mitsis, E, Shah, R, Detoledo-Morrell, L, Duara, R, Varon, D, Greig, M, Roberts, P, Albert, M, Onyike, C, D'Agostino, D, Kielb, S, Galvin, J, Cerbone, B, Michel, C, Pogorelec, D, Rusinek, H, De Leon, M, Glodzik, L, De Santi, S, Doraiswamy, P, Petrella, J, Borges-Neto, S, Wong, T, Coleman, E, Smith, C, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Porsteinsson, A, Goldstein, B, Martin, K, Makino, K, Ismail, M, Brand, C, Mulnard, R, Thai, G, Mc-Adams-Ortiz, C, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Cellar, J, Burns, J, Swerdlow, R, Brooks, W, Apostolova, L, Tingus, K, Woo, E, Silverman, D, Lu, P, Bartzokis, G, Graf-Radford, N, Parftt, F, Kendall, T, Johnson, H, Farlow, M, Hake, AM, Matthews, B, Brosch, J, Herring, S, Hunt, C, Dyck, C, Carson, R, MacAvoy, M, Varma, P, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Robin Hsiung, GY, Feldman, H, Mudge, B, Assaly, M, Finger, E, Pasternack, S, Rachisky, I, Trost, D, Kertesz, A, Bernick, C, Munic, D, Mesulam, MM, Lipowski, K, Weintraub, S, Bonakdarpour, B, Kerwin, D, Wu, CK, Johnson, N, Sadowsky, C, Villena, T, Turner, RS, Johnson, K, Reynolds, B, Sperling, R, Johnson, K, Marshall, G, Yesavage, J, Taylor, J, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, M, Belden, C, Jacobson, S, Sirrel, S, Kowall, N, Killiany, R, Budson, A, Norbash, A, Johnson, PL, Obisesan, T, Wolday, S, Allard, J, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Kittur, S, Borrie, M, Lee, TY, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Potkin, S, Preda, A, Nguyen, D, Tariot, P, Burke, A, Trncic, N, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, D, Kataki, M, Adeli, A, Zimmerman, E, Celmins, D, Brown, A, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Sink, K, Gordineer, L, Williamson, J, Garg, P, Watkins, F, Ott, B, Querfurth, H, Tremont, G, Salloway, S, Malloy, P, Correia, S, Rosen, H, Miller, B, Perry, D, Mintzer, J, Spicer, K, Bachman, D, Pomara, N, Hernando, R, Sarrael, A, Relkin, N, Chaing, G, Lin, M, Ravdin, L, Smith, A, Raj, BA & Fargher, K 2018, 'Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states', Scientific Reports, vol. 8, no. 1, 4103. https://doi.org/10.1038/s41598-018-21568-7
Mahjoub, Ines ; Mahjoub, Mohamed Ali ; Rekik, Islem ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Cliford ; Jagust, William ; Trojanowki, John ; Toga, Arthur ; Beckett, Laurel ; Green, Robert ; Saykin, Andrew ; Morris, John ; Shaw, Leslie ; Kaye, Jeffrey ; Quinn, Joseph ; Silbert, Lisa ; Lind, Betty ; Carter, Raina ; Dolen, Sara ; Schneider, Lon ; Pawluczyk, Sonia ; Beccera, Mauricio ; Teodoro, Liberty ; Spann, Bryan ; Brewer, James ; Vanderswag, Helen ; Fleisher, Adam ; Heidebrink, Judith ; Lord, Joanne ; Mason, Sara ; Albers, Colleen ; Knopman, David ; Johnson, Kris ; Doody, Rachelle ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Rountree, Susan ; Dang, Mimi ; Stern, Yaakov ; Honig, Lawrence ; Bell, Karen ; Ances, Beau ; Carroll, Maria ; Creech, Mary ; Franklin, Erin ; Mintun, Mark ; Schneider, Stacy ; Oliver, Angela ; Marson, Daniel ; Grifth, Randall ; Clark, David ; Geldmacher, David ; Brockington, John ; Roberson, Erik ; Natelson Love, Marissa ; Grossman, Hillel ; Mitsis, Efe ; Shah, Raj ; Detoledo-Morrell, Leyla ; Duara, Ranjan ; Varon, Daniel ; Greig, Maria ; Roberts, Peggy ; Albert, Marilyn ; Onyike, Chiadi ; D'Agostino, Daniel ; Kielb, Stephanie ; Galvin, James ; Cerbone, Brittany ; Michel, Christina ; Pogorelec, Dana ; Rusinek, Henry ; De Leon, Mony ; Glodzik, Lidia ; De Santi, Susan ; Doraiswamy, P. ; Petrella, Jefrey ; Borges-Neto, Salvador ; Wong, Terence ; Coleman, Edward ; Smith, Charles ; Jicha, Greg ; Hardy, Peter ; Sinha, Partha ; Oates, Elizabeth ; Conrad, Gary ; Porsteinsson, Anton ; Goldstein, Bonnie ; Martin, Kim ; Makino, Kelly ; Ismail, M. ; Brand, Connie ; Mulnard, Ruth ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Levey, Allan ; Lah, James ; Cellar, Janet ; Burns, Jefrey ; Swerdlow, Russell ; Brooks, William ; Apostolova, Liana ; Tingus, Kathleen ; Woo, Ellen ; Silverman, Daniel ; Lu, Po ; Bartzokis, George ; Graf-Radford, Neill ; Parftt, Francine ; Kendall, Tracy ; Johnson, Heather ; Farlow, Martin ; Hake, Ann Marie ; Matthews, Brandy ; Brosch, Jared ; Herring, Scott ; Hunt, Cynthia ; Dyck, Christopher ; Carson, Richard ; MacAvoy, Martha ; Varma, Pradeep ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Caldwell, Curtis ; Robin Hsiung, Ging Yuek ; Feldman, Howard ; Mudge, Benita ; Assaly, Michele ; Finger, Elizabeth ; Pasternack, Stephen ; Rachisky, Irina ; Trost, Dick ; Kertesz, Andrew ; Bernick, Charles ; Munic, Donna ; Mesulam, Marek Marsel ; Lipowski, Kristine ; Weintraub, Sandra ; Bonakdarpour, Borna ; Kerwin, Diana ; Wu, Chuang Kuo ; Johnson, Nancy ; Sadowsky, Carl ; Villena, Teresa ; Turner, Raymond Scott ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa ; Johnson, Keith ; Marshall, Gad ; Yesavage, Jerome ; Taylor, Joy ; Lane, Barton ; Rosen, Allyson ; Tinklenberg, Jared ; Sabbagh, Marwan ; Belden, Christine ; Jacobson, Sandra ; Sirrel, Sherye ; Kowall, Neil ; Killiany, Ronald ; Budson, Andrew ; Norbash, Alexander ; Johnson, Patricia Lynn ; Obisesan, Thomas ; Wolday, Saba ; Allard, Joanne ; Lerner, Alan ; Ogrocki, Paula ; Tatsuoka, Curtis ; Fatica, Parianne ; Fletcher, Evan ; Maillard, Pauline ; Olichney, John ; Decarli, Charles ; Carmichael, Owen ; Kittur, Smita ; Borrie, Michael ; Lee, T. Y. ; Bartha, Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia ; Potkin, Steven ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Burke, Anna ; Trncic, Nadira ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Scharre, Douglas ; Kataki, Maria ; Adeli, Anahita ; Zimmerman, Earl ; Celmins, Dzintra ; Brown, Alice ; Pearlson, Godfrey ; Blank, Karen ; Anderson, Karen ; Flashman, Laura ; Seltzer, Marc ; Hynes, Mary ; Santulli, Robert ; Sink, Kaycee ; Gordineer, Leslie ; Williamson, Jef ; Garg, Pradeep ; Watkins, Franklin ; Ott, Brian ; Querfurth, Henry ; Tremont, Geofrey ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen ; Rosen, Howard ; Miller, Bruce ; Perry, David ; Mintzer, Jacobo ; Spicer, Kenneth ; Bachman, David ; Pomara, Nunzio ; Hernando, Raymundo ; Sarrael, Antero ; Relkin, Norman ; Chaing, Gloria ; Lin, Michael ; Ravdin, Lisa ; Smith, Amanda ; Raj, Balebail Ashok ; Fargher, Kristin. / Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
@article{bb23f5b8994d4a698a0800f50d53d5e5,
title = "Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states",
abstract = "Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus.",
author = "Ines Mahjoub and Mahjoub, {Mohamed Ali} and Islem Rekik and Michael Weiner and Paul Aisen and Ronald Petersen and Cliford Jack and William Jagust and John Trojanowki and Arthur Toga and Laurel Beckett and Robert Green and Andrew Saykin and John Morris and Leslie Shaw and Jeffrey Kaye and Joseph Quinn and Lisa Silbert and Betty Lind and Raina Carter and Sara Dolen and Lon Schneider and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Bryan Spann and James Brewer and Helen Vanderswag and Adam Fleisher and Judith Heidebrink and Joanne Lord and Sara Mason and Colleen Albers and David Knopman and Kris Johnson and Rachelle Doody and Javier Villanueva-Meyer and Munir Chowdhury and Susan Rountree and Mimi Dang and Yaakov Stern and Lawrence Honig and Karen Bell and Beau Ances and Maria Carroll and Mary Creech and Erin Franklin and Mark Mintun and Stacy Schneider and Angela Oliver and Daniel Marson and Randall Grifth and David Clark and David Geldmacher and John Brockington and Erik Roberson and {Natelson Love}, Marissa and Hillel Grossman and Efe Mitsis and Raj Shah and Leyla Detoledo-Morrell and Ranjan Duara and Daniel Varon and Maria Greig and Peggy Roberts and Marilyn Albert and Chiadi Onyike and Daniel D'Agostino and Stephanie Kielb and James Galvin and Brittany Cerbone and Christina Michel and Dana Pogorelec and Henry Rusinek and {De Leon}, Mony and Lidia Glodzik and {De Santi}, Susan and P. Doraiswamy and Jefrey Petrella and Salvador Borges-Neto and Terence Wong and Edward Coleman and Charles Smith and Greg Jicha and Peter Hardy and Partha Sinha and Elizabeth Oates and Gary Conrad and Anton Porsteinsson and Bonnie Goldstein and Kim Martin and Kelly Makino and M. Ismail and Connie Brand and Ruth Mulnard and Gaby Thai and Catherine Mc-Adams-Ortiz and Kyle Womack and Dana Mathews and Mary Quiceno and Allan Levey and James Lah and Janet Cellar and Jefrey Burns and Russell Swerdlow and William Brooks and Liana Apostolova and Kathleen Tingus and Ellen Woo and Daniel Silverman and Po Lu and George Bartzokis and Neill Graf-Radford and Francine Parftt and Tracy Kendall and Heather Johnson and Martin Farlow and Hake, {Ann Marie} and Brandy Matthews and Jared Brosch and Scott Herring and Cynthia Hunt and Christopher Dyck and Richard Carson and Martha MacAvoy and Pradeep Varma and Howard Chertkow and Howard Bergman and Chris Hosein and Sandra Black and Bojana Stefanovic and Curtis Caldwell and {Robin Hsiung}, {Ging Yuek} and Howard Feldman and Benita Mudge and Michele Assaly and Elizabeth Finger and Stephen Pasternack and Irina Rachisky and Dick Trost and Andrew Kertesz and Charles Bernick and Donna Munic and Mesulam, {Marek Marsel} and Kristine Lipowski and Sandra Weintraub and Borna Bonakdarpour and Diana Kerwin and Wu, {Chuang Kuo} and Nancy Johnson and Carl Sadowsky and Teresa Villena and Turner, {Raymond Scott} and Kathleen Johnson and Brigid Reynolds and Reisa Sperling and Keith Johnson and Gad Marshall and Jerome Yesavage and Joy Taylor and Barton Lane and Allyson Rosen and Jared Tinklenberg and Marwan Sabbagh and Christine Belden and Sandra Jacobson and Sherye Sirrel and Neil Kowall and Ronald Killiany and Andrew Budson and Alexander Norbash and Johnson, {Patricia Lynn} and Thomas Obisesan and Saba Wolday and Joanne Allard and Alan Lerner and Paula Ogrocki and Curtis Tatsuoka and Parianne Fatica and Evan Fletcher and Pauline Maillard and John Olichney and Charles Decarli and Owen Carmichael and Smita Kittur and Michael Borrie and Lee, {T. Y.} and Rob Bartha and Sterling Johnson and Sanjay Asthana and Cynthia Carlsson and Steven Potkin and Adrian Preda and Dana Nguyen and Pierre Tariot and Anna Burke and Nadira Trncic and Stephanie Reeder and Vernice Bates and Horacio Capote and Michelle Rainka and Douglas Scharre and Maria Kataki and Anahita Adeli and Earl Zimmerman and Dzintra Celmins and Alice Brown and Godfrey Pearlson and Karen Blank and Karen Anderson and Laura Flashman and Marc Seltzer and Mary Hynes and Robert Santulli and Kaycee Sink and Leslie Gordineer and Jef Williamson and Pradeep Garg and Franklin Watkins and Brian Ott and Henry Querfurth and Geofrey Tremont and Stephen Salloway and Paul Malloy and Stephen Correia and Howard Rosen and Bruce Miller and David Perry and Jacobo Mintzer and Kenneth Spicer and David Bachman and Nunzio Pomara and Raymundo Hernando and Antero Sarrael and Norman Relkin and Gloria Chaing and Michael Lin and Lisa Ravdin and Amanda Smith and Raj, {Balebail Ashok} and Kristin Fargher",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-21568-7",
language = "English (US)",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

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TY - JOUR

T1 - Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

AU - Mahjoub, Ines

AU - Mahjoub, Mohamed Ali

AU - Rekik, Islem

AU - Weiner, Michael

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Cliford

AU - Jagust, William

AU - Trojanowki, John

AU - Toga, Arthur

AU - Beckett, Laurel

AU - Green, Robert

AU - Saykin, Andrew

AU - Morris, John

AU - Shaw, Leslie

AU - Kaye, Jeffrey

AU - Quinn, Joseph

AU - Silbert, Lisa

AU - Lind, Betty

AU - Carter, Raina

AU - Dolen, Sara

AU - Schneider, Lon

AU - Pawluczyk, Sonia

AU - Beccera, Mauricio

AU - Teodoro, Liberty

AU - Spann, Bryan

AU - Brewer, James

AU - Vanderswag, Helen

AU - Fleisher, Adam

AU - Heidebrink, Judith

AU - Lord, Joanne

AU - Mason, Sara

AU - Albers, Colleen

AU - Knopman, David

AU - Johnson, Kris

AU - Doody, Rachelle

AU - Villanueva-Meyer, Javier

AU - Chowdhury, Munir

AU - Rountree, Susan

AU - Dang, Mimi

AU - Stern, Yaakov

AU - Honig, Lawrence

AU - Bell, Karen

AU - Ances, Beau

AU - Carroll, Maria

AU - Creech, Mary

AU - Franklin, Erin

AU - Mintun, Mark

AU - Schneider, Stacy

AU - Oliver, Angela

AU - Marson, Daniel

AU - Grifth, Randall

AU - Clark, David

AU - Geldmacher, David

AU - Brockington, John

AU - Roberson, Erik

AU - Natelson Love, Marissa

AU - Grossman, Hillel

AU - Mitsis, Efe

AU - Shah, Raj

AU - Detoledo-Morrell, Leyla

AU - Duara, Ranjan

AU - Varon, Daniel

AU - Greig, Maria

AU - Roberts, Peggy

AU - Albert, Marilyn

AU - Onyike, Chiadi

AU - D'Agostino, Daniel

AU - Kielb, Stephanie

AU - Galvin, James

AU - Cerbone, Brittany

AU - Michel, Christina

AU - Pogorelec, Dana

AU - Rusinek, Henry

AU - De Leon, Mony

AU - Glodzik, Lidia

AU - De Santi, Susan

AU - Doraiswamy, P.

AU - Petrella, Jefrey

AU - Borges-Neto, Salvador

AU - Wong, Terence

AU - Coleman, Edward

AU - Smith, Charles

AU - Jicha, Greg

AU - Hardy, Peter

AU - Sinha, Partha

AU - Oates, Elizabeth

AU - Conrad, Gary

AU - Porsteinsson, Anton

AU - Goldstein, Bonnie

AU - Martin, Kim

AU - Makino, Kelly

AU - Ismail, M.

AU - Brand, Connie

AU - Mulnard, Ruth

AU - Thai, Gaby

AU - Mc-Adams-Ortiz, Catherine

AU - Womack, Kyle

AU - Mathews, Dana

AU - Quiceno, Mary

AU - Levey, Allan

AU - Lah, James

AU - Cellar, Janet

AU - Burns, Jefrey

AU - Swerdlow, Russell

AU - Brooks, William

AU - Apostolova, Liana

AU - Tingus, Kathleen

AU - Woo, Ellen

AU - Silverman, Daniel

AU - Lu, Po

AU - Bartzokis, George

AU - Graf-Radford, Neill

AU - Parftt, Francine

AU - Kendall, Tracy

AU - Johnson, Heather

AU - Farlow, Martin

AU - Hake, Ann Marie

AU - Matthews, Brandy

AU - Brosch, Jared

AU - Herring, Scott

AU - Hunt, Cynthia

AU - Dyck, Christopher

AU - Carson, Richard

AU - MacAvoy, Martha

AU - Varma, Pradeep

AU - Chertkow, Howard

AU - Bergman, Howard

AU - Hosein, Chris

AU - Black, Sandra

AU - Stefanovic, Bojana

AU - Caldwell, Curtis

AU - Robin Hsiung, Ging Yuek

AU - Feldman, Howard

AU - Mudge, Benita

AU - Assaly, Michele

AU - Finger, Elizabeth

AU - Pasternack, Stephen

AU - Rachisky, Irina

AU - Trost, Dick

AU - Kertesz, Andrew

AU - Bernick, Charles

AU - Munic, Donna

AU - Mesulam, Marek Marsel

AU - Lipowski, Kristine

AU - Weintraub, Sandra

AU - Bonakdarpour, Borna

AU - Kerwin, Diana

AU - Wu, Chuang Kuo

AU - Johnson, Nancy

AU - Sadowsky, Carl

AU - Villena, Teresa

AU - Turner, Raymond Scott

AU - Johnson, Kathleen

AU - Reynolds, Brigid

AU - Sperling, Reisa

AU - Johnson, Keith

AU - Marshall, Gad

AU - Yesavage, Jerome

AU - Taylor, Joy

AU - Lane, Barton

AU - Rosen, Allyson

AU - Tinklenberg, Jared

AU - Sabbagh, Marwan

AU - Belden, Christine

AU - Jacobson, Sandra

AU - Sirrel, Sherye

AU - Kowall, Neil

AU - Killiany, Ronald

AU - Budson, Andrew

AU - Norbash, Alexander

AU - Johnson, Patricia Lynn

AU - Obisesan, Thomas

AU - Wolday, Saba

AU - Allard, Joanne

AU - Lerner, Alan

AU - Ogrocki, Paula

AU - Tatsuoka, Curtis

AU - Fatica, Parianne

AU - Fletcher, Evan

AU - Maillard, Pauline

AU - Olichney, John

AU - Decarli, Charles

AU - Carmichael, Owen

AU - Kittur, Smita

AU - Borrie, Michael

AU - Lee, T. Y.

AU - Bartha, Rob

AU - Johnson, Sterling

AU - Asthana, Sanjay

AU - Carlsson, Cynthia

AU - Potkin, Steven

AU - Preda, Adrian

AU - Nguyen, Dana

AU - Tariot, Pierre

AU - Burke, Anna

AU - Trncic, Nadira

AU - Reeder, Stephanie

AU - Bates, Vernice

AU - Capote, Horacio

AU - Rainka, Michelle

AU - Scharre, Douglas

AU - Kataki, Maria

AU - Adeli, Anahita

AU - Zimmerman, Earl

AU - Celmins, Dzintra

AU - Brown, Alice

AU - Pearlson, Godfrey

AU - Blank, Karen

AU - Anderson, Karen

AU - Flashman, Laura

AU - Seltzer, Marc

AU - Hynes, Mary

AU - Santulli, Robert

AU - Sink, Kaycee

AU - Gordineer, Leslie

AU - Williamson, Jef

AU - Garg, Pradeep

AU - Watkins, Franklin

AU - Ott, Brian

AU - Querfurth, Henry

AU - Tremont, Geofrey

AU - Salloway, Stephen

AU - Malloy, Paul

AU - Correia, Stephen

AU - Rosen, Howard

AU - Miller, Bruce

AU - Perry, David

AU - Mintzer, Jacobo

AU - Spicer, Kenneth

AU - Bachman, David

AU - Pomara, Nunzio

AU - Hernando, Raymundo

AU - Sarrael, Antero

AU - Relkin, Norman

AU - Chaing, Gloria

AU - Lin, Michael

AU - Ravdin, Lisa

AU - Smith, Amanda

AU - Raj, Balebail Ashok

AU - Fargher, Kristin

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus.

AB - Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus.

UR - http://www.scopus.com/inward/record.url?scp=85048280147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048280147&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-21568-7

DO - 10.1038/s41598-018-21568-7

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 4103

ER -