Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Ines Mahjoub, Mohamed Ali Mahjoub, Islem Rekik, Michael Weiner, Paul Aisen, Ronald Petersen, Cliford Jack, William Jagust, John Trojanowki, Arthur Toga, Laurel Beckett, Robert Green, Andrew Saykin, John Morris, Leslie Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina CarterSara Dolen, Lon Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith Heidebrink, Joanne Lord, Sara Mason, Colleen Albers, David Knopman, Kris Johnson, Rachelle Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence Honig, Karen Bell, Beau Ances, Maria Carroll, Mary Creech, Erin Franklin, Mark Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Grifth, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Efe Mitsis, Raj Shah, Leyla Detoledo-Morrell, Ranjan Duara, Daniel Varon, Maria Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James Galvin, Brittany Cerbone, Christina Michel, Dana Pogorelec, Henry Rusinek, Mony De Leon, Lidia Glodzik, Susan De Santi, P. Doraiswamy, Jefrey Petrella, Salvador Borges-Neto, Terence Wong, Edward Coleman, Charles Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton Porsteinsson, Bonnie Goldstein, Kim Martin, Kelly Makino, M. Ismail, Connie Brand, Ruth Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan Levey, James Lah, Janet Cellar, Jefrey Burns, Russell Swerdlow, William Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po Lu, George Bartzokis, Neill Graf-Radford, Francine Parftt, Tracy Kendall, Heather Johnson, Martin Farlow, Ann Marie Hake, Brandy Matthews, Jared Brosch, Scott Herring, Cynthia Hunt, Christopher Dyck, Richard Carson, Martha MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa Sperling, Keith Johnson, Gad Marshall, Jerome Yesavage, Joy Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan Sabbagh, Christine Belden, Sandra Jacobson, Sherye Sirrel, Neil Kowall, Ronald Killiany, Andrew Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles Decarli, Owen Carmichael, Smita Kittur, Michael Borrie, T. Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia Carlsson, Steven Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas Scharre, Maria Kataki, Anahita Adeli, Earl Zimmerman, Dzintra Celmins, Alice Brown, Godfrey Pearlson, Karen Blank, Karen Anderson, Laura Flashman, Marc Seltzer, Mary Hynes, Robert Santulli, Kaycee Sink, Leslie Gordineer, Jef Williamson, Pradeep Garg, Franklin Watkins, Brian Ott, Henry Querfurth, Geofrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard Rosen, Bruce Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher

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Abstract

Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus.

Original languageEnglish (US)
Article number4103
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Mahjoub, I., Mahjoub, M. A., Rekik, I., Weiner, M., Aisen, P., Petersen, R., Jack, C., Jagust, W., Trojanowki, J., Toga, A., Beckett, L., Green, R., Saykin, A., Morris, J., Shaw, L., Kaye, J., Quinn, J., Silbert, L., Lind, B., ... Fargher, K. (2018). Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states. Scientific Reports, 8(1), [4103]. https://doi.org/10.1038/s41598-018-21568-7