Abstract
Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are neural stem cells, capable of self-renewing and generating neurons and glia. Cues within the niche, from cell-cell interactions to diffusible factors, are spatially and temporally coordinated to regulate proliferation and neurogenesis, ultimately affecting stem cell fate choices. Here, we review the components of adult neural stem cell niches and how they act to regulate neurogenesis in these regions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 123-137 |
| Number of pages | 15 |
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 363 |
| Issue number | 1489 |
| DOIs | |
| State | Published - Jan 12 2008 |
| Externally published | Yes |
Keywords
- Astrocyte
- Niche
- Stem cell
- Subgranular zone
- Subventricular zone
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)