Brain micro-ecologies: Neural stem cell niches in the adult mammalian brain

Patricio A. Riquelme, Elodie Drapeau, Fiona Doetsch

Research output: Contribution to journalReview article

188 Scopus citations

Abstract

Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are neural stem cells, capable of self-renewing and generating neurons and glia. Cues within the niche, from cell-cell interactions to diffusible factors, are spatially and temporally coordinated to regulate proliferation and neurogenesis, ultimately affecting stem cell fate choices. Here, we review the components of adult neural stem cell niches and how they act to regulate neurogenesis in these regions.

Original languageEnglish (US)
Pages (from-to)123-137
Number of pages15
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume363
Issue number1489
DOIs
StatePublished - Jan 12 2008

Keywords

  • Astrocyte
  • Niche
  • Stem cell
  • Subgranular zone
  • Subventricular zone

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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