Brain metabolite concentration and dementia severity in Alzheimer's disease: A 1H MRS study

Wei Huang, G. E. Alexander, L. Chang, H. U. Shetty, J. S. Krasuski, S. I. Rapoport, Mark B. Schapiro

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Objective: 1H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whether they change as dementia severity worsens. Methods: The authors used 1H-MRS with external standards to measure absolute brain concentrations of mI, NAA, total creatine (Cr), and choline (Cho)-containing compounds in 21 subjects with AD and 17 age- and sex-matched controls in occipital and left and right parietal regions. Results: Concentrations of NAA were significantly decreased, whereas mI and Cr concentrations were significantly increased in all three brain regions in subjects with AD compared with controls. Higher concentrations of mI and Cr occurred even in mild AD. A discriminant analysis of the 1H-MRS data combined with CSF volume measurements distinguished subjects with AD, ranging from mild to severe dementia, from controls with 100% correct classification. NAA concentration, though not other metabolites, was positively correlated with Mini-Mental State Examination score. Conclusion: The measurements with 1H-MRS of absolute metabolite concentrations in the neocortex showed abnormal concentrations of brain metabolites in AD; these metabolite concentrations do not necessarily correlate with disease severity. Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity. Further, subjects with mild AD can be differentiated from controls with 1H-MRS.

Original languageEnglish (US)
Pages (from-to)626-632
Number of pages7
JournalNeurology
Volume57
Issue number4
StatePublished - Aug 28 2001
Externally publishedYes

Fingerprint

Inositol
Dementia
Alzheimer Disease
Creatine
Brain
Parietal Lobe
Neocortex
Discriminant Analysis
Choline
Proton Magnetic Resonance Spectroscopy
N-acetylaspartate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Huang, W., Alexander, G. E., Chang, L., Shetty, H. U., Krasuski, J. S., Rapoport, S. I., & Schapiro, M. B. (2001). Brain metabolite concentration and dementia severity in Alzheimer's disease: A 1H MRS study. Neurology, 57(4), 626-632.

Brain metabolite concentration and dementia severity in Alzheimer's disease : A 1H MRS study. / Huang, Wei; Alexander, G. E.; Chang, L.; Shetty, H. U.; Krasuski, J. S.; Rapoport, S. I.; Schapiro, Mark B.

In: Neurology, Vol. 57, No. 4, 28.08.2001, p. 626-632.

Research output: Contribution to journalArticle

Huang, W, Alexander, GE, Chang, L, Shetty, HU, Krasuski, JS, Rapoport, SI & Schapiro, MB 2001, 'Brain metabolite concentration and dementia severity in Alzheimer's disease: A 1H MRS study', Neurology, vol. 57, no. 4, pp. 626-632.
Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, Rapoport SI et al. Brain metabolite concentration and dementia severity in Alzheimer's disease: A 1H MRS study. Neurology. 2001 Aug 28;57(4):626-632.
Huang, Wei ; Alexander, G. E. ; Chang, L. ; Shetty, H. U. ; Krasuski, J. S. ; Rapoport, S. I. ; Schapiro, Mark B. / Brain metabolite concentration and dementia severity in Alzheimer's disease : A 1H MRS study. In: Neurology. 2001 ; Vol. 57, No. 4. pp. 626-632.
@article{971d12f28df74ba790f7fe926c91c923,
title = "Brain metabolite concentration and dementia severity in Alzheimer's disease: A 1H MRS study",
abstract = "Objective: 1H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whether they change as dementia severity worsens. Methods: The authors used 1H-MRS with external standards to measure absolute brain concentrations of mI, NAA, total creatine (Cr), and choline (Cho)-containing compounds in 21 subjects with AD and 17 age- and sex-matched controls in occipital and left and right parietal regions. Results: Concentrations of NAA were significantly decreased, whereas mI and Cr concentrations were significantly increased in all three brain regions in subjects with AD compared with controls. Higher concentrations of mI and Cr occurred even in mild AD. A discriminant analysis of the 1H-MRS data combined with CSF volume measurements distinguished subjects with AD, ranging from mild to severe dementia, from controls with 100{\%} correct classification. NAA concentration, though not other metabolites, was positively correlated with Mini-Mental State Examination score. Conclusion: The measurements with 1H-MRS of absolute metabolite concentrations in the neocortex showed abnormal concentrations of brain metabolites in AD; these metabolite concentrations do not necessarily correlate with disease severity. Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity. Further, subjects with mild AD can be differentiated from controls with 1H-MRS.",
author = "Wei Huang and Alexander, {G. E.} and L. Chang and Shetty, {H. U.} and Krasuski, {J. S.} and Rapoport, {S. I.} and Schapiro, {Mark B.}",
year = "2001",
month = "8",
day = "28",
language = "English (US)",
volume = "57",
pages = "626--632",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Brain metabolite concentration and dementia severity in Alzheimer's disease

T2 - A 1H MRS study

AU - Huang, Wei

AU - Alexander, G. E.

AU - Chang, L.

AU - Shetty, H. U.

AU - Krasuski, J. S.

AU - Rapoport, S. I.

AU - Schapiro, Mark B.

PY - 2001/8/28

Y1 - 2001/8/28

N2 - Objective: 1H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whether they change as dementia severity worsens. Methods: The authors used 1H-MRS with external standards to measure absolute brain concentrations of mI, NAA, total creatine (Cr), and choline (Cho)-containing compounds in 21 subjects with AD and 17 age- and sex-matched controls in occipital and left and right parietal regions. Results: Concentrations of NAA were significantly decreased, whereas mI and Cr concentrations were significantly increased in all three brain regions in subjects with AD compared with controls. Higher concentrations of mI and Cr occurred even in mild AD. A discriminant analysis of the 1H-MRS data combined with CSF volume measurements distinguished subjects with AD, ranging from mild to severe dementia, from controls with 100% correct classification. NAA concentration, though not other metabolites, was positively correlated with Mini-Mental State Examination score. Conclusion: The measurements with 1H-MRS of absolute metabolite concentrations in the neocortex showed abnormal concentrations of brain metabolites in AD; these metabolite concentrations do not necessarily correlate with disease severity. Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity. Further, subjects with mild AD can be differentiated from controls with 1H-MRS.

AB - Objective: 1H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whether they change as dementia severity worsens. Methods: The authors used 1H-MRS with external standards to measure absolute brain concentrations of mI, NAA, total creatine (Cr), and choline (Cho)-containing compounds in 21 subjects with AD and 17 age- and sex-matched controls in occipital and left and right parietal regions. Results: Concentrations of NAA were significantly decreased, whereas mI and Cr concentrations were significantly increased in all three brain regions in subjects with AD compared with controls. Higher concentrations of mI and Cr occurred even in mild AD. A discriminant analysis of the 1H-MRS data combined with CSF volume measurements distinguished subjects with AD, ranging from mild to severe dementia, from controls with 100% correct classification. NAA concentration, though not other metabolites, was positively correlated with Mini-Mental State Examination score. Conclusion: The measurements with 1H-MRS of absolute metabolite concentrations in the neocortex showed abnormal concentrations of brain metabolites in AD; these metabolite concentrations do not necessarily correlate with disease severity. Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity. Further, subjects with mild AD can be differentiated from controls with 1H-MRS.

UR - http://www.scopus.com/inward/record.url?scp=0035964302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035964302&partnerID=8YFLogxK

M3 - Article

C2 - 11524470

AN - SCOPUS:0035964302

VL - 57

SP - 626

EP - 632

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -