Brain locations controlling the behavioral effects of chronic amphetamine intoxication

Robert Hitzemann, Jerwin Wu, Dennis Hom, Horace Loh

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Rats were administered d-amphetamine repeatedly for 4days. After day 1 of treatment, the amphetamine-induced increases in ambulation, rearing, and stereotyped activity were augmented. However, after 4 dats treatment, the rearing and ambulatory responses became attenuated while the stereotyped activities remained augmented. Microinjection studies revealed that both the augmentation and attenuation of nonstereotyped ambulation were generated from the nucleus accumbens. The augmentation of stereotyped behaviors was generated from the caudate nucleus. Chronically treated animals who were administered 0.7 but not 1.0 mg/kg apomorphine showed augmented behavioral response. Chronic amphetamine treatment significantly decreased (3H) spiroperidol binding in both the nucleus accumbens and caudate nucleus. However, no effect on the DA-stimulated adenyl cyclase activity was observed in either brain region. It is concluded that repeated d-amphetamine administration selectively augments and attenuates d-amphetamine-induced behaviours and that these selective effects are mediated by different dopamine systems.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalPsychopharmacology
Volume72
Issue number1
DOIs
StatePublished - Dec 1980
Externally publishedYes

Fingerprint

Dextroamphetamine
Amphetamine
Caudate Nucleus
Nucleus Accumbens
Walking
Brain
Stereotyped Behavior
Spiperone
Apomorphine
Microinjections
Adenylyl Cyclases
Dopamine
Therapeutics

Keywords

  • Behavior
  • Caudate nucleus
  • Dopamine
  • Nucleus accumbens
  • Repeated amphetamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Brain locations controlling the behavioral effects of chronic amphetamine intoxication. / Hitzemann, Robert; Wu, Jerwin; Hom, Dennis; Loh, Horace.

In: Psychopharmacology, Vol. 72, No. 1, 12.1980, p. 93-101.

Research output: Contribution to journalArticle

Hitzemann, Robert ; Wu, Jerwin ; Hom, Dennis ; Loh, Horace. / Brain locations controlling the behavioral effects of chronic amphetamine intoxication. In: Psychopharmacology. 1980 ; Vol. 72, No. 1. pp. 93-101.
@article{d4705a6a27ae4ca8ae9349464bcce8bb,
title = "Brain locations controlling the behavioral effects of chronic amphetamine intoxication",
abstract = "Rats were administered d-amphetamine repeatedly for 4days. After day 1 of treatment, the amphetamine-induced increases in ambulation, rearing, and stereotyped activity were augmented. However, after 4 dats treatment, the rearing and ambulatory responses became attenuated while the stereotyped activities remained augmented. Microinjection studies revealed that both the augmentation and attenuation of nonstereotyped ambulation were generated from the nucleus accumbens. The augmentation of stereotyped behaviors was generated from the caudate nucleus. Chronically treated animals who were administered 0.7 but not 1.0 mg/kg apomorphine showed augmented behavioral response. Chronic amphetamine treatment significantly decreased (3H) spiroperidol binding in both the nucleus accumbens and caudate nucleus. However, no effect on the DA-stimulated adenyl cyclase activity was observed in either brain region. It is concluded that repeated d-amphetamine administration selectively augments and attenuates d-amphetamine-induced behaviours and that these selective effects are mediated by different dopamine systems.",
keywords = "Behavior, Caudate nucleus, Dopamine, Nucleus accumbens, Repeated amphetamine",
author = "Robert Hitzemann and Jerwin Wu and Dennis Hom and Horace Loh",
year = "1980",
month = "12",
doi = "10.1007/BF00433812",
language = "English (US)",
volume = "72",
pages = "93--101",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Brain locations controlling the behavioral effects of chronic amphetamine intoxication

AU - Hitzemann, Robert

AU - Wu, Jerwin

AU - Hom, Dennis

AU - Loh, Horace

PY - 1980/12

Y1 - 1980/12

N2 - Rats were administered d-amphetamine repeatedly for 4days. After day 1 of treatment, the amphetamine-induced increases in ambulation, rearing, and stereotyped activity were augmented. However, after 4 dats treatment, the rearing and ambulatory responses became attenuated while the stereotyped activities remained augmented. Microinjection studies revealed that both the augmentation and attenuation of nonstereotyped ambulation were generated from the nucleus accumbens. The augmentation of stereotyped behaviors was generated from the caudate nucleus. Chronically treated animals who were administered 0.7 but not 1.0 mg/kg apomorphine showed augmented behavioral response. Chronic amphetamine treatment significantly decreased (3H) spiroperidol binding in both the nucleus accumbens and caudate nucleus. However, no effect on the DA-stimulated adenyl cyclase activity was observed in either brain region. It is concluded that repeated d-amphetamine administration selectively augments and attenuates d-amphetamine-induced behaviours and that these selective effects are mediated by different dopamine systems.

AB - Rats were administered d-amphetamine repeatedly for 4days. After day 1 of treatment, the amphetamine-induced increases in ambulation, rearing, and stereotyped activity were augmented. However, after 4 dats treatment, the rearing and ambulatory responses became attenuated while the stereotyped activities remained augmented. Microinjection studies revealed that both the augmentation and attenuation of nonstereotyped ambulation were generated from the nucleus accumbens. The augmentation of stereotyped behaviors was generated from the caudate nucleus. Chronically treated animals who were administered 0.7 but not 1.0 mg/kg apomorphine showed augmented behavioral response. Chronic amphetamine treatment significantly decreased (3H) spiroperidol binding in both the nucleus accumbens and caudate nucleus. However, no effect on the DA-stimulated adenyl cyclase activity was observed in either brain region. It is concluded that repeated d-amphetamine administration selectively augments and attenuates d-amphetamine-induced behaviours and that these selective effects are mediated by different dopamine systems.

KW - Behavior

KW - Caudate nucleus

KW - Dopamine

KW - Nucleus accumbens

KW - Repeated amphetamine

UR - http://www.scopus.com/inward/record.url?scp=0019126988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019126988&partnerID=8YFLogxK

U2 - 10.1007/BF00433812

DO - 10.1007/BF00433812

M3 - Article

C2 - 6162168

AN - SCOPUS:0019126988

VL - 72

SP - 93

EP - 101

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -