Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

Tracey A. Rouault, De Liang Zhang, Suh Young Jeong

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.

Original languageEnglish (US)
Pages (from-to)673-684
Number of pages12
JournalMetabolic brain disease
Volume24
Issue number4
DOIs
StatePublished - Dec 2009
Externally publishedYes

Keywords

  • Blood brain barrier
  • Blood-CSF barrier
  • Ceruloplasmin
  • Choroid plexus
  • Ferroportin
  • Iron transport

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins'. Together they form a unique fingerprint.

Cite this