Brain fibroblast growth factors do not stimulate myelination or remyelination in tissue culture

Fred C. Westall, Fredrick J. Seil, William R. Woodward, Denis Gospodarowicz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Myelin basic protein fragments that stimulated proliferation of fibroblasts in vitro did not enhance myelin formation or remyelination in nervous system tissue cultures. Similar fragments are present during demyelination in multiple sclerosis, but the lack of myelin stimulating activity in vitro suggests that they may not play a role in remyelination in vivo.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalJournal of the neurological sciences
Volume52
Issue number2-3
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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