Brain fibroblast growth factors do not stimulate myelination or remyelination in tissue culture

Fred C. Westall, Fredrick J. Seil, William Woodward, Denis Gospodarowicz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myelin basic protein fragments that stimulated proliferation of fibroblasts in vitro did not enhance myelin formation or remyelination in nervous system tissue cultures. Similar fragments are present during demyelination in multiple sclerosis, but the lack of myelin stimulating activity in vitro suggests that they may not play a role in remyelination in vivo.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalJournal of the Neurological Sciences
Volume52
Issue number2-3
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Fibroblast Growth Factors
Myelin Sheath
Nerve Tissue
Myelin Basic Protein
Brain
Demyelinating Diseases
Nervous System
Multiple Sclerosis
Fibroblasts
In Vitro Techniques

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Brain fibroblast growth factors do not stimulate myelination or remyelination in tissue culture. / Westall, Fred C.; Seil, Fredrick J.; Woodward, William; Gospodarowicz, Denis.

In: Journal of the Neurological Sciences, Vol. 52, No. 2-3, 1981, p. 239-243.

Research output: Contribution to journalArticle

Westall, Fred C. ; Seil, Fredrick J. ; Woodward, William ; Gospodarowicz, Denis. / Brain fibroblast growth factors do not stimulate myelination or remyelination in tissue culture. In: Journal of the Neurological Sciences. 1981 ; Vol. 52, No. 2-3. pp. 239-243.
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