TY - JOUR
T1 - Brain fibroblast growth factors do not stimulate myelination or remyelination in tissue culture
AU - Westall, Fred C.
AU - Seil, Fredrick J.
AU - Woodward, William R.
AU - Gospodarowicz, Denis
N1 - Funding Information:
Supported by Multiple Sclerosis Society Grant RG 1204-A-3 and NIH Grant NS 11391 IFCW),
PY - 1981
Y1 - 1981
N2 - Myelin basic protein fragments that stimulated proliferation of fibroblasts in vitro did not enhance myelin formation or remyelination in nervous system tissue cultures. Similar fragments are present during demyelination in multiple sclerosis, but the lack of myelin stimulating activity in vitro suggests that they may not play a role in remyelination in vivo.
AB - Myelin basic protein fragments that stimulated proliferation of fibroblasts in vitro did not enhance myelin formation or remyelination in nervous system tissue cultures. Similar fragments are present during demyelination in multiple sclerosis, but the lack of myelin stimulating activity in vitro suggests that they may not play a role in remyelination in vivo.
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U2 - 10.1016/0022-510X(81)90008-3
DO - 10.1016/0022-510X(81)90008-3
M3 - Article
C2 - 6171619
AN - SCOPUS:0019511820
SN - 0022-510X
VL - 52
SP - 239
EP - 243
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 2-3
ER -