Brain-dependent TSH secretion from heterotopic pituitaries

John Kendall, S. I. Shimoda, M. A. Greer

Research output: Contribution to journalArticle

Abstract

Male rats bearing multiple heterotopic pituitaries under the renal capsule were hypophysectomized. Two weeks later the effects of propylthiouracil feeding on thyroid size and of forebrain removal on thyroid radioiodine metabolism were studied. Two weeks of propylthiouracil feeding failed to induce goiter formation in hypophysectomized rats with 2 to 16 pituitaries. In hypophysectomized rats with 10 heterotopic pituitaries, complete forebrain removal, but not cerebral decortication, reduced the 4-h thyroidal uptake of 131I and formation of 131I-labeled iodothyronines one day following brain operations. This finding suggests that the subcortical forebrain maintains the TSH secretion of heterotopic pituitaries. Presumably TRF is secreted by the subcortical forebrain and passes through the general circulation to stimulate TSH secretion of heterotopic pituitaries. Apparently the level of TRF reaching heterotopic pituitaries through the general circulation never can attain the levels reached in the hypophyseal portal system.

Original languageEnglish (US)
Pages (from-to)76-87
Number of pages12
JournalNeuroendocrinology
Volume2
Issue number2
DOIs
StatePublished - 1967

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Prosencephalon
Propylthiouracil
Brain
Cerebral Decortication
Thyroid Gland
Portal System
Goiter
Capsules
Kidney

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Brain-dependent TSH secretion from heterotopic pituitaries. / Kendall, John; Shimoda, S. I.; Greer, M. A.

In: Neuroendocrinology, Vol. 2, No. 2, 1967, p. 76-87.

Research output: Contribution to journalArticle

Kendall, J, Shimoda, SI & Greer, MA 1967, 'Brain-dependent TSH secretion from heterotopic pituitaries', Neuroendocrinology, vol. 2, no. 2, pp. 76-87. https://doi.org/10.1159/000121533
Kendall, John ; Shimoda, S. I. ; Greer, M. A. / Brain-dependent TSH secretion from heterotopic pituitaries. In: Neuroendocrinology. 1967 ; Vol. 2, No. 2. pp. 76-87.
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