Brachytherapy for prostate cancer: Endorectal mr imaging of local treatment-related changes

Fergus Coakley, Hedvig Hricak, Antje E. Wefer, Joycelyn L. Speight, John Kurhanewicz, Mack Roach

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

PURPOSE: To determine the local treatment-related endorectal magnetic resonance (MR) imaging findings after brachytherapy for prostate cancer. MATERIALS AND METHODS: Endorectal MR imaging was performed in 35 consecutive patients at a mean interval of 12 months (range, 1-31 months) after brachytherapy for prostate cancer. Transverse T1-weighted and high-spatial-resolution transverse and coronal T2-weighted images were acquired. Two readers reviewed MR image quality and findings, with discrepancies resolved by consensus. Posttreatment urinary symptoms in patients (n = 24) were documented by using chart review. RESULTS: All studies were of diagnostic quality. On T2-weighted images, prostatic findings consisted of diffuse low signal intensity (n = 35) and indistinct zonal anatomy (n = 34). Intra- and extraprostatic seed locations could be distinguished. The most common extraprostatic site of seed implantation was the neurovascular bundles (n = 35, bilateral in 32). The most common extraprostatic tissue finding was increased signal intensity on T2-weighted images in the levator ani muscle (n = 34) and the genitourinary diaphragm (n = 28). Postbrachytherapy urinary symptoms showed no demonstrable correlation with periurethral or genitourinary sympphragm seed implantation or with signal intensity change in the genitourinary diaphragm. CONCLUSION: Endorectal MR imaging can be used to evaluate seed distribution and to demonstrate treatment-related changes after brachytherapy for prostate Cancer.

Original languageEnglish (US)
Pages (from-to)817-821
Number of pages5
JournalRadiology
Volume219
Issue number3
StatePublished - Jun 2001
Externally publishedYes

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Brachytherapy
Prostatic Neoplasms
Seeds
Magnetic Resonance Imaging
Diaphragm
Anal Canal
Therapeutics
Anatomy
Magnetic Resonance Spectroscopy
Muscles

Keywords

  • Prostate neoplasms, MR, 844.32
  • Prostate neoplasms, therapeutic radiology, 844.12168, 844.32
  • Radiations, injurious effects, complications of therapeutic radiology, 84.47

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Coakley, F., Hricak, H., Wefer, A. E., Speight, J. L., Kurhanewicz, J., & Roach, M. (2001). Brachytherapy for prostate cancer: Endorectal mr imaging of local treatment-related changes. Radiology, 219(3), 817-821.

Brachytherapy for prostate cancer : Endorectal mr imaging of local treatment-related changes. / Coakley, Fergus; Hricak, Hedvig; Wefer, Antje E.; Speight, Joycelyn L.; Kurhanewicz, John; Roach, Mack.

In: Radiology, Vol. 219, No. 3, 06.2001, p. 817-821.

Research output: Contribution to journalArticle

Coakley, F, Hricak, H, Wefer, AE, Speight, JL, Kurhanewicz, J & Roach, M 2001, 'Brachytherapy for prostate cancer: Endorectal mr imaging of local treatment-related changes', Radiology, vol. 219, no. 3, pp. 817-821.
Coakley F, Hricak H, Wefer AE, Speight JL, Kurhanewicz J, Roach M. Brachytherapy for prostate cancer: Endorectal mr imaging of local treatment-related changes. Radiology. 2001 Jun;219(3):817-821.
Coakley, Fergus ; Hricak, Hedvig ; Wefer, Antje E. ; Speight, Joycelyn L. ; Kurhanewicz, John ; Roach, Mack. / Brachytherapy for prostate cancer : Endorectal mr imaging of local treatment-related changes. In: Radiology. 2001 ; Vol. 219, No. 3. pp. 817-821.
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AB - PURPOSE: To determine the local treatment-related endorectal magnetic resonance (MR) imaging findings after brachytherapy for prostate cancer. MATERIALS AND METHODS: Endorectal MR imaging was performed in 35 consecutive patients at a mean interval of 12 months (range, 1-31 months) after brachytherapy for prostate cancer. Transverse T1-weighted and high-spatial-resolution transverse and coronal T2-weighted images were acquired. Two readers reviewed MR image quality and findings, with discrepancies resolved by consensus. Posttreatment urinary symptoms in patients (n = 24) were documented by using chart review. RESULTS: All studies were of diagnostic quality. On T2-weighted images, prostatic findings consisted of diffuse low signal intensity (n = 35) and indistinct zonal anatomy (n = 34). Intra- and extraprostatic seed locations could be distinguished. The most common extraprostatic site of seed implantation was the neurovascular bundles (n = 35, bilateral in 32). The most common extraprostatic tissue finding was increased signal intensity on T2-weighted images in the levator ani muscle (n = 34) and the genitourinary diaphragm (n = 28). Postbrachytherapy urinary symptoms showed no demonstrable correlation with periurethral or genitourinary sympphragm seed implantation or with signal intensity change in the genitourinary diaphragm. CONCLUSION: Endorectal MR imaging can be used to evaluate seed distribution and to demonstrate treatment-related changes after brachytherapy for prostate Cancer.

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