Botulinum toxin treatment in gastrointestinal disorders

Ammar Nassri; Kaveh Sharzehi; Ron Schey

doi:10.1007/978-3-030-50691-9_14

Botulinum toxin treatment in gastrointestinal disorders

Ammar Nassri, Kaveh Sharzehi, Ron Schey

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Botulinum toxin is used extensively for the management of gastrointestinal smooth muscle disorders. This chapter is a summary of the current status of this therapy. Botulinum toxin appears to be beneficial for achalasia, hypertensive esophageal disorders, and anal fissure and unclear utility in gastroparesis, upper esophageal sphincter dysfunction, and sphincter of Oddi dysfunction. Very few placebo-controlled trials have been performed despite widespread use of toxin for the past 25 years. Botulinum toxin appears to be safe and side effects are uncommon. Despite uncontrolled data, botulinum toxin is now used for a variety of spastic disorders of GI smooth muscle. In some instances, this therapy may preclude the need for more invasive treatments. Controlled trials are needed.

Original language	English (US)
Title of host publication	Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine
Publisher	Springer
Pages	283-295
Number of pages	13
ISBN (Electronic)	9783030506919
ISBN (Print)	9783030506902
DOIs	https://doi.org/10.1007/978-3-030-50691-9_14
State	Published - Oct 6 2020

Keywords

Achalasia
Anal fissure
Botulinum toxin
Gastroparesis
Hypertensive esophageal disorders
Sphincter of Oddi dysfunction

ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Dentistry(all)
veterinary(all)

Access to Document

10.1007/978-3-030-50691-9_14

Cite this

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abstract = "Botulinum toxin is used extensively for the management of gastrointestinal smooth muscle disorders. This chapter is a summary of the current status of this therapy. Botulinum toxin appears to be beneficial for achalasia, hypertensive esophageal disorders, and anal fissure and unclear utility in gastroparesis, upper esophageal sphincter dysfunction, and sphincter of Oddi dysfunction. Very few placebo-controlled trials have been performed despite widespread use of toxin for the past 25 years. Botulinum toxin appears to be safe and side effects are uncommon. Despite uncontrolled data, botulinum toxin is now used for a variety of spastic disorders of GI smooth muscle. In some instances, this therapy may preclude the need for more invasive treatments. Controlled trials are needed.",

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KW - Hypertensive esophageal disorders

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Botulinum toxin treatment in gastrointestinal disorders

Abstract

Keywords

ASJC Scopus subject areas

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