Bone-muscle indices as risk factors for fractures in Men

The osteoporotic fractures in men (MrOS) study

A. K O Wong, P. M. Cawthon, K. W. Peters, S. R. Cummings, C. L. Gordon, Y. Sheu, K. Ensrud, M. Petit, J. M. Zmuda, Eric Orwoll, J. Cauley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To assess bone-muscle (B-M) indices as risk factors for incident fractures in men.

Methods: Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.

Results: In 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m2, 4.1±0.9 follow-up years, 7.7% of men ≥1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.

Conclusion: Mass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD.

Original languageEnglish (US)
Pages (from-to)246-254
Number of pages9
JournalJournal of Musculoskeletal Neuronal Interactions
Volume14
Issue number3
StatePublished - Sep 1 2014

Fingerprint

Osteoporotic Fractures
Bone and Bones
Muscles
Bone Density
Pelvic Bones
Muscle Strength
Body Mass Index
Bone Fractures
Photon Absorptiometry
Body Composition
Spine
Odds Ratio
Tomography

Keywords

  • Bone-Muscle indices
  • Discriminative power
  • DXA
  • Full body composition
  • Incident fractures
  • Men
  • Osteoporosis
  • pQCT

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Physiology

Cite this

Wong, A. K. O., Cawthon, P. M., Peters, K. W., Cummings, S. R., Gordon, C. L., Sheu, Y., ... Cauley, J. (2014). Bone-muscle indices as risk factors for fractures in Men: The osteoporotic fractures in men (MrOS) study. Journal of Musculoskeletal Neuronal Interactions, 14(3), 246-254.

Bone-muscle indices as risk factors for fractures in Men : The osteoporotic fractures in men (MrOS) study. / Wong, A. K O; Cawthon, P. M.; Peters, K. W.; Cummings, S. R.; Gordon, C. L.; Sheu, Y.; Ensrud, K.; Petit, M.; Zmuda, J. M.; Orwoll, Eric; Cauley, J.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 14, No. 3, 01.09.2014, p. 246-254.

Research output: Contribution to journalArticle

Wong, AKO, Cawthon, PM, Peters, KW, Cummings, SR, Gordon, CL, Sheu, Y, Ensrud, K, Petit, M, Zmuda, JM, Orwoll, E & Cauley, J 2014, 'Bone-muscle indices as risk factors for fractures in Men: The osteoporotic fractures in men (MrOS) study', Journal of Musculoskeletal Neuronal Interactions, vol. 14, no. 3, pp. 246-254.
Wong, A. K O ; Cawthon, P. M. ; Peters, K. W. ; Cummings, S. R. ; Gordon, C. L. ; Sheu, Y. ; Ensrud, K. ; Petit, M. ; Zmuda, J. M. ; Orwoll, Eric ; Cauley, J. / Bone-muscle indices as risk factors for fractures in Men : The osteoporotic fractures in men (MrOS) study. In: Journal of Musculoskeletal Neuronal Interactions. 2014 ; Vol. 14, No. 3. pp. 246-254.
@article{a9d8b25ea9844ddc9102013a18253dfa,
title = "Bone-muscle indices as risk factors for fractures in Men: The osteoporotic fractures in men (MrOS) study",
abstract = "Objective: To assess bone-muscle (B-M) indices as risk factors for incident fractures in men.Methods: Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66{\%} of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.Results: In 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m2, 4.1±0.9 follow-up years, 7.7{\%} of men ≥1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.Conclusion: Mass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD.",
keywords = "Bone-Muscle indices, Discriminative power, DXA, Full body composition, Incident fractures, Men, Osteoporosis, pQCT",
author = "Wong, {A. K O} and Cawthon, {P. M.} and Peters, {K. W.} and Cummings, {S. R.} and Gordon, {C. L.} and Y. Sheu and K. Ensrud and M. Petit and Zmuda, {J. M.} and Eric Orwoll and J. Cauley",
year = "2014",
month = "9",
day = "1",
language = "English (US)",
volume = "14",
pages = "246--254",
journal = "Journal of Musculoskeletal Neuronal Interactions",
issn = "1108-7161",
publisher = "International Society of Musculoskeletal and Neuronal Interactions",
number = "3",

}

TY - JOUR

T1 - Bone-muscle indices as risk factors for fractures in Men

T2 - The osteoporotic fractures in men (MrOS) study

AU - Wong, A. K O

AU - Cawthon, P. M.

AU - Peters, K. W.

AU - Cummings, S. R.

AU - Gordon, C. L.

AU - Sheu, Y.

AU - Ensrud, K.

AU - Petit, M.

AU - Zmuda, J. M.

AU - Orwoll, Eric

AU - Cauley, J.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Objective: To assess bone-muscle (B-M) indices as risk factors for incident fractures in men.Methods: Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.Results: In 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m2, 4.1±0.9 follow-up years, 7.7% of men ≥1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.Conclusion: Mass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD.

AB - Objective: To assess bone-muscle (B-M) indices as risk factors for incident fractures in men.Methods: Participants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.Results: In 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m2, 4.1±0.9 follow-up years, 7.7% of men ≥1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.Conclusion: Mass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD.

KW - Bone-Muscle indices

KW - Discriminative power

KW - DXA

KW - Full body composition

KW - Incident fractures

KW - Men

KW - Osteoporosis

KW - pQCT

UR - http://www.scopus.com/inward/record.url?scp=84907056542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907056542&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 246

EP - 254

JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

SN - 1108-7161

IS - 3

ER -