Bone morphogenetic proteins and degenerative disk disease

Khoi D. Than, Shayan U. Rahman, Monique J. Vanaman, Anthony C. Wang, Chia Ying Lin, Huina Zhang, Frank La Marca, Paul Park

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Bone morphogenetic proteins (BMPs) are involved not only in osteogenesis but also in chondrogenesis. They play an important role in the development and maintenance of the intervertebral disk (IVD). For this reason, an increasing amount of research has been performed to examine the relationship between BMPs and degenerative disk disease (DDD). Moreover, researchers are examining the safe use of BMPs as a potential treatment for diskogenic back pain. We performed a literature search using databases from the US National Library of Medicine and the National Institutes of Health to identify studies relating BMPs to DDD. According to in vitro and in vivo studies in different animal and human IVDs, BMP-2 and BMP-7 are upregulated with aging and with induced disk injury; this represents an anabolic response. Direct administration of BMP-2 to IVD cells results in increased production of components of the extracellular matrix. Upregulation of the BMP pathway via other agents, namely simvastatin and LIM mineralization protein-1, has resulted in similar outcomes. Adenoviruses loaded with BMPs, transfected either directly to IVD cells or via articular chondrocytic vectors, also resulted in reversal of the typical findings in DDD. We conclude that the use of BMPs to treat DDD has a promising future. Further studies are indicated to determine optimal delivery and efficacy in humans.

Original languageEnglish (US)
Pages (from-to)996-1002
Number of pages7
JournalNeurosurgery
Volume70
Issue number4
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Keywords

  • Back pain
  • Bone morphogenetic protein
  • Degenerative disk disease
  • Intervertebral disk
  • Review

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Than, K. D., Rahman, S. U., Vanaman, M. J., Wang, A. C., Lin, C. Y., Zhang, H., La Marca, F., & Park, P. (2012). Bone morphogenetic proteins and degenerative disk disease. Neurosurgery, 70(4), 996-1002. https://doi.org/10.1227/NEU.0b013e318235d65f