Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect

Adam S. Deconde, Douglas Sidell, Min Lee, Olga Bezouglaia, Kyle Low, David Elashoff, Tristan Grogan, Sotirios Tetradis, Tara Aghaloo, Maie St. John

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives/Hypothesis To test the osteoregenerative potential and dosing of bone morphogenetic protein-2 (BMP-2)-impregnated biomimetic scaffolds in a rat model of a mandibular defect. Study Design Prospective study using an animal model. Methods Varied doses of BMP-2 (0.5, 1, 0.5, 0.5 in microspheres, 5, and 15 μg) were absorbed onto a biomimetic scaffold. Scaffolds were then implanted into marginal mandibular defects in rats. Blank scaffolds and unfilled defects were used as negative controls. Two months postoperatively, bone healing was analyzed with microcomputerized tomography (microCT). Results MicroCT analysis demonstrated that all doses of BMP-2 induced successful healing of marginal mandibular defects in a rat mandible. Increasing doses of BMP-2 on the scaffolds produced increased tissue healing, with 15 μg demonstrating significantly more healing than all other dosing (P

Original languageEnglish (US)
Pages (from-to)1149-1155
Number of pages7
JournalLaryngoscope
Volume123
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Bone Morphogenetic Protein 2
Biomimetics
Bone and Bones
X-Ray Microtomography
Mandible
Microspheres
Animal Models
Tomography
Prospective Studies

Keywords

  • Biomaterials
  • craniofacial
  • Level of Evidence: NA
  • mandible
  • osteogenesis
  • tissue engineering

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Deconde, A. S., Sidell, D., Lee, M., Bezouglaia, O., Low, K., Elashoff, D., ... St. John, M. (2013). Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect. Laryngoscope, 123(5), 1149-1155. https://doi.org/10.1002/lary.23782

Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect. / Deconde, Adam S.; Sidell, Douglas; Lee, Min; Bezouglaia, Olga; Low, Kyle; Elashoff, David; Grogan, Tristan; Tetradis, Sotirios; Aghaloo, Tara; St. John, Maie.

In: Laryngoscope, Vol. 123, No. 5, 05.2013, p. 1149-1155.

Research output: Contribution to journalArticle

Deconde, AS, Sidell, D, Lee, M, Bezouglaia, O, Low, K, Elashoff, D, Grogan, T, Tetradis, S, Aghaloo, T & St. John, M 2013, 'Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect', Laryngoscope, vol. 123, no. 5, pp. 1149-1155. https://doi.org/10.1002/lary.23782
Deconde, Adam S. ; Sidell, Douglas ; Lee, Min ; Bezouglaia, Olga ; Low, Kyle ; Elashoff, David ; Grogan, Tristan ; Tetradis, Sotirios ; Aghaloo, Tara ; St. John, Maie. / Bone morphogenetic protein-2-impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect. In: Laryngoscope. 2013 ; Vol. 123, No. 5. pp. 1149-1155.
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