TY - JOUR
T1 - Bone mineral density of the lumbar spine in women with endometriosis
AU - Lane, N.
AU - Baptista, J.
AU - Orwoll, E.
N1 - Funding Information:
Received May 7, 1990; revised and accepted October 24, 1990. * Supported by Syntex Laboratories, Inc., Palo Alto, California. t Syntex Laboratories, Inc., Palo Alto, California. :j: University of California at San Francisco. §Reprint requests: Nancy Lane, M.D., Syntex Laboratories, L-2400, 3401 Hillview Avenue, Palo Alto, California 94304. II Medical Service, Portland Veterans Association Medical Center and Department of Medicine, Oregon Health Services University.
PY - 1991
Y1 - 1991
N2 - Young women with endometriosis have reduced cortical and trabecular bone mineral density of the wrist compared with age-matched controls. This conclusion was based on 41 subjects from one geographical location. The purpose of this study was to test this finding in a larger, more geographically diverse population. One hundred women with laparoscopically proven endometriosis were enrolled in this study for the evaluation of the efficacy of nafarelin, a gonadotropin-releasing hormone agonist. Patients were recruited from nine investigators across the United States and Canada, and bone mineral density of the lumbar spine was obtained at baseline, with 6 Hologic QDR (Hologic Inc., Waltham, MA) and a Lunar DPX (Lunar Radiation Corp., Madison, WI) instrument. The age of the women was 30.3 ± 5.8 years (mean ± SD); 91% were white. Bone mineral density of the lumbar spine was 1.1 ± 0.11 g/cm2 (n = 85 Hologic QDR) and 1.2 ± 0.93 g/cm2 (n = 15 Lunar DPX). Hologic bone mineral density was 104.8 ± 11.0 and Lunar bone mineral density was 103.4% ± 7.8% of normal values for age. To conclude, in a population based cross-sectional study of patients with endometriosis, we do not observe low bone mineral density of the lumbar spine by techniques that measure a combination of cortical and trabecular bone.
AB - Young women with endometriosis have reduced cortical and trabecular bone mineral density of the wrist compared with age-matched controls. This conclusion was based on 41 subjects from one geographical location. The purpose of this study was to test this finding in a larger, more geographically diverse population. One hundred women with laparoscopically proven endometriosis were enrolled in this study for the evaluation of the efficacy of nafarelin, a gonadotropin-releasing hormone agonist. Patients were recruited from nine investigators across the United States and Canada, and bone mineral density of the lumbar spine was obtained at baseline, with 6 Hologic QDR (Hologic Inc., Waltham, MA) and a Lunar DPX (Lunar Radiation Corp., Madison, WI) instrument. The age of the women was 30.3 ± 5.8 years (mean ± SD); 91% were white. Bone mineral density of the lumbar spine was 1.1 ± 0.11 g/cm2 (n = 85 Hologic QDR) and 1.2 ± 0.93 g/cm2 (n = 15 Lunar DPX). Hologic bone mineral density was 104.8 ± 11.0 and Lunar bone mineral density was 103.4% ± 7.8% of normal values for age. To conclude, in a population based cross-sectional study of patients with endometriosis, we do not observe low bone mineral density of the lumbar spine by techniques that measure a combination of cortical and trabecular bone.
UR - http://www.scopus.com/inward/record.url?scp=0026065117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026065117&partnerID=8YFLogxK
U2 - 10.1016/s0015-0282(16)54181-8
DO - 10.1016/s0015-0282(16)54181-8
M3 - Article
C2 - 2001755
AN - SCOPUS:0026065117
SN - 0015-0282
VL - 55
SP - 537
EP - 542
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -