Young women with endometriosis have reduced cortical and trabecular bone mineral density of the wrist compared with age-matched controls. This conclusion was based on 41 subjects from one geographical location. The purpose of this study was to test this finding in a larger, more geographically diverse population. One hundred women with laparoscopically proven endometriosis were enrolled in this study for the evaluation of the efficacy of nafarelin, a gonadotropin-releasing hormone agonist. Patients were recruited from nine investigators across the United States and Canada, and bone mineral density of the lumbar spine was obtained at baseline, with 6 Hologic QDR (Hologic Inc., Waltham, MA) and a Lunar DPX (Lunar Radiation Corp., Madison, WI) instrument. The age of the women was 30.3 ± 5.8 years (mean ± SD); 91% were white. Bone mineral density of the lumbar spine was 1.1 ± 0.11 g/cm2 (n = 85 Hologic QDR) and 1.2 ± 0.93 g/cm2 (n = 15 Lunar DPX). Hologic bone mineral density was 104.8 ± 11.0 and Lunar bone mineral density was 103.4% ± 7.8% of normal values for age. To conclude, in a population based cross-sectional study of patients with endometriosis, we do not observe low bone mineral density of the lumbar spine by techniques that measure a combination of cortical and trabecular bone.
|Original language||English (US)|
|Number of pages||6|
|Journal||Fertility and sterility|
|State||Published - Jan 1 1991|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology