Bone marrow-derived hepatocytes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Scopus citations

Abstract

Several independent reports have demonstrated that bone marrow cells can give rise to different hepatic epithelial cells types, including oval cells, hepatocytes and duct epithelium. These observations have resulted in the hypothesis that bone marrow resident stem cells, specifically haematopoietic stem cells, are an important source for liver epithelial cell replacement, particularly during chronic injury. However, the bulk of published data on the role of bone marrow stem cells in liver damage suggest that they do not play a significant physiological role in replacement of epithelial cells in any known form of hepatic injury. Fully functional bone marrow-derived hepatocytes indeed exist, but are extremely rare and are generated by cell fusion, not stem cell differentiation.

Original languageEnglish (US)
Title of host publicationStem Cells
Subtitle of host publicationNuclear Reprogramming and Therapeutic Applications
Pages20-27
Number of pages8
StatePublished - Dec 1 2005

Publication series

NameNovartis Foundation Symposium
Volume265
ISSN (Print)1528-2511

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Grompe, M. (2005). Bone marrow-derived hepatocytes. In Stem Cells: Nuclear Reprogramming and Therapeutic Applications (pp. 20-27). (Novartis Foundation Symposium; Vol. 265).