Bone marrow-derived cells fuse with normal and transformed intestinal stem cells

Adnan Z. Rizvi, John R. Swain, Paige Davies, Alexis S. Bailey, Adria D. Decker, Holger Willenbring, Markus Grompe, William Fleming, Melissa Wong

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Transplanted adult bone marrow-derived cells (BMDCs) have been shown to adopt the phenotype and function of several nonhematopoietic cell lineages and promote tumorigenesis. Beyond its cancer enhancing potential, cell fusion has recently emerged as an explanation of how BMDCs regenerate diseased heptocytes, contribute to Purkinje neurons and skeletal and cardiac muscle cells, and participate in skin and heart regeneration. Although bone marrow-derived epithelial cells also have been observed in the intestine, fusion as a mechanism has not been investigated. Here, we show that transplanted BMDCs fuse with both normal and neoplastic intestinal epithelium. Long-term repopulation by donor-derived cells was detected in all principal intestinal epithelial lineages including enterocytes, goblet cells, Paneth cells, and enteroendocrine cells, suggesting that the fusion partners of the BMDCs are long-lived intestinal progenitors or stem cells. Fusion of BMDCs with neoplastic epithelium did not result in tumor initiation. Our findings suggest an unexpected role for BMDCs in both regeneration and tumorigenesis of the intestine.

Original languageEnglish (US)
Pages (from-to)6321-6325
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number16
DOIs
StatePublished - Apr 18 2006

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Bone Marrow Cells
Stem Cells
Cell Fusion
Intestines
Regeneration
Carcinogenesis
Paneth Cells
Enteroendocrine Cells
Goblet Cells
Enterocytes
Purkinje Cells
Cell Lineage
Intestinal Mucosa
Cardiac Myocytes
Neoplasms
Skeletal Muscle
Epithelium
Bone Marrow
Epithelial Cells
Phenotype

Keywords

  • Cell fusion
  • Intestine
  • Tissue regeneration
  • Tumorigenesis

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. / Rizvi, Adnan Z.; Swain, John R.; Davies, Paige; Bailey, Alexis S.; Decker, Adria D.; Willenbring, Holger; Grompe, Markus; Fleming, William; Wong, Melissa.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 16, 18.04.2006, p. 6321-6325.

Research output: Contribution to journalArticle

Rizvi, Adnan Z. ; Swain, John R. ; Davies, Paige ; Bailey, Alexis S. ; Decker, Adria D. ; Willenbring, Holger ; Grompe, Markus ; Fleming, William ; Wong, Melissa. / Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 16. pp. 6321-6325.
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